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  1. The treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is complex. In addition to disease control, important therapeutic goals are the maintenance of normal growth and the acqui...

    Authors: Todd D. Nebesio and Erica A. Eugster

    Citation: International Journal of Pediatric Endocrinology 2010 2010:298937

    Content type: Review Article

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  2. We report a familial case of the nephrogenic syndrome of inappropriate antidiuresis (NSIAD), including 30-year followup data on two patients. The proband and one maternal uncle presented in their infancy with ...

    Authors: Yoon Hi Cho, Stephen Gitelman, Stephen Rosenthal and Geoffrey Ambler

    Citation: International Journal of Pediatric Endocrinology 2009 2009:431527

    Content type: Case Report

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  3. Three infants with ambiguous genitalia and suspected ovotestes were given recombinant FSH to induce ovarian follicular development. The development of follicles in the gonadal tissue suggested the presence of ...

    Authors: Shannon French, Luisa Rodriguez, Alan Schlesinger, Laurence McCullough, Jennifer Dietrich, John Hicks and Lefkothea Karaviti

    Citation: International Journal of Pediatric Endocrinology 2009 2009:507964

    Content type: Case Report

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  4. Objective. To assess the growth and control of adrenal androgen secretion in children with virilizing congenital adrenal hyperplasia (CAH) treated with dexamethasone. Method. We examined doses used, control of ad...

    Authors: Scott A. Rivkees and Kerry Stephenson

    Citation: International Journal of Pediatric Endocrinology 2009 2009:274682

    Content type: Research Article

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  5. We report an interesting case of a 17-year-old normal-statured female who was diagnosed with congenital panhypopituitarism due to pituitary hypoplasia at the presentation of bilateral slipped capital femoral e...

    Authors: Sasigarn A. Bowden and Kevin E. Klingele

    Citation: International Journal of Pediatric Endocrinology 2009 2009:609131

    Content type: Case Report

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  6. The choice of therapeutic strategies for hyperthyroidism during pregnancy is limited. Surgery and radioiodine are typically avoided, leaving propylthiouracil and methimazole in the US. Carbimazole, a metabolic...

    Authors: Albert R. Cunningham, C. Alex Carrasquer and Donald R. Mattison

    Citation: International Journal of Pediatric Endocrinology 2009 2009:936154

    Content type: Research Article

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  7. Data accumulated over recent years have significantly advanced our understanding of growth factors, cytokines, and hormones in breast milk. Here we deal with leptin, adiponectin, IGF-I, ghrelin, and the more r...

    Authors: Francesco Savino, Stefania A. Liguori, Maria F. Fissore and Roberto Oggero

    Citation: International Journal of Pediatric Endocrinology 2009 2009:327505

    Content type: Review Article

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  8. Cushing syndrome is rare in infancy and usually due to an adrenocortical tumor (ACT). We report an infant with Cushing syndrome due to adrenocortical carcinoma. The patient presented at six months of age with ...

    Authors: ElizabethB Fudge, Daniel von Allmen, KeithE Volmar and AliS Calikoglu

    Citation: International Journal of Pediatric Endocrinology 2009 2009:168749

    Content type: Case Report

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  9. The incidence of overweight and obesity is rising at an alarming pace in the pediatric population, just as in the adult population. The adult comorbidities associated with this risk factor are well-recognized ...

    Authors: Darren M. Allcock, Michael J. Gardner and James R. Sowers

    Citation: International Journal of Pediatric Endocrinology 2009 2009:108187

    Content type: Review Article

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  10. Objectives. We investigate whether parents complaining of their children's short stature have misconception of their height. Methods. Parents were asked to report their own height and were then measured. We compa...

    Authors: Paulo F. Collett-Solberg and Pedro R. Collett-Solberg

    Citation: International Journal of Pediatric Endocrinology 2009 2009:919405

    Content type: Research Article

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  11. Objectives. (1) Determine the predictive value of a school-based test of cardiovascular fitness (CVF) for insulin resistance (IR); (2) compare a "school-based" prediction of IR to a "laboratory-based" prediction,...

    Authors: Todd Varness, Aaron L. Carrel, Jens C. Eickhoff and David B. Allen

    Citation: International Journal of Pediatric Endocrinology 2009 2009:487804

    Content type: Research Article

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  12. The most common monogenic cause of neonatal diabetes is mutation in KCNJ11, which encodes a potassium channel in pancreatic beta cells. Some mutations in this gene, including Q52R, have been described in assoc...

    Authors: Natalie D. Shaw and Joseph A. Majzoub

    Citation: International Journal of Pediatric Endocrinology 2009 2009:453240

    Content type: Case Report

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  13. Objectives. To determine if the low iron state described in obese children is associated with the chronic inflammatory state seen in obesity. Study Design. Obese children age from 2 to 19 years seen at a weight m...

    Authors: MatthewW Richardson, Leybie Ang, PaulF Visintainer and ChrystalA Wittcopp

    Citation: International Journal of Pediatric Endocrinology 2009 2009:713269

    Content type: Clinical Study

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  14. Disorders of sex development refer to a collection of congenital conditions in which atypical development of chromosomal, gonadal, or anatomic sex occurs. Studies of 46,XY DSD have focused largely on gender id...

    Authors: Amy B. Wisniewski and Tom Mazur

    Citation: International Journal of Pediatric Endocrinology 2009 2009:567430

    Content type: Review Article

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  15. The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated....

    Authors: Ruimin Chen, Gail J. Mick, Rongxian Xu, Daoxin Zheng, Yanfeng Fan, Xiangquan Lin and Kenneth L. McCormick

    Citation: International Journal of Pediatric Endocrinology 2009 2009:194807

    Content type: Research Article

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  16. As the first wave of biopharmaceuticals is set to expire, biosimilars or follow-on protein products (FOPPs) have emerged. The regulatory foundation for these products is more advanced and better codified in Eu...

    Authors: Paul Saenger

    Citation: International Journal of Pediatric Endocrinology 2009 2009:370329

    Content type: Review Article

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  17. Hyponatremia with hyperkalemia in infancy is an uncommon but life-threatening occurrence. In the first weeks of life, this scenario is often associated with aldosterone deficiency due to salt-wasting congenita...

    Authors: Radha Nandagopal, Priya Vaidyanathan and Paul Kaplowitz

    Citation: International Journal of Pediatric Endocrinology 2009 2009:195728

    Content type: Case Report

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  18. This study examined changes in insulin resistance (IR) in 120 youth over two years. IR was quantified via homeostatic model (HOMA-IR), and weight status changes were quantified via body mass index (BMI). When ...

    Authors: Kristin S. Ondrak, Robert G. McMurray, Claudio L. Battaglini, Kelly R. Evenson and Joanne S. Harrell

    Citation: International Journal of Pediatric Endocrinology 2009 2009:862061

    Content type: Research Article

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  19. Propylthiouracil (PTU) was introduced for clinical use in July 1947 for Graves' disease (GD) treatment. Over the 60 years that this medication has been used, reports of PTU-related liver failure and death have...

    Authors: Scott A. Rivkees and Donald R. Mattison

    Citation: International Journal of Pediatric Endocrinology 2009 2009:132041

    Content type: Commentary

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  20. Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyon...

    Authors: Stefanie Leniszewski and Richard Mauseth

    Citation: International Journal of Pediatric Endocrinology 2009 2009:628034

    Content type: Case Report

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  21. Background. Gonadotropin releasing hormone analogs (GnRHas) are standard of care for central precocious puberty (CPP). The histrelin subcutaneous implant is safe and effective in the treatment of CPP for one year...

    Authors: Samar Rahhal, William L. Clarke, Gad B. Kletter, Peter A. Lee, E. Kirk Neely, Edward O. Reiter, Paul Saenger, Dorothy Shulman, Lawrence Silverman and Erica A. Eugster

    Citation: International Journal of Pediatric Endocrinology 2009 2009:812517

    Content type: Clinical Study

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  22. Galactocele is a benign breast lesion, usually occurring in nursing women. This lesion is a rare cause of breast enlargement in children. In this paper we describe the case of an infant with hyperprolactinemia...

    Authors: Paolo A. Tomasi, Giuseppe Fanciulli, Tiziana Casti and Giuseppe Delitala

    Citation: International Journal of Pediatric Endocrinology 2009 2009:578610

    Content type: Case Report

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  23. In adult patients with congenital adrenal hyperplasia (CAH), the presence of testicular adrenal rest tumours (TART) is an important complication leading to gonadal dysfunction and infertility. These tumours ca...

    Authors: H. L. Claahsen-van der Grinten, A. R. M. M. Hermus and B. J. Otten

    Citation: International Journal of Pediatric Endocrinology 2009 2009:624823

    Content type: Review Article

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  24. The Constant Carbohydrate diet, based entirely on carbohydrate exchanges, is now widely used in the dietary treatment of diabetes mellitus. Being based on sound scientific principles and simple in design, the ...

    Authors: Charles Herbert Read Jr.

    Citation: International Journal of Pediatric Endocrinology 2008 2009:469623

    Content type: Commentary

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  25. Obesity is a significant cause of morbidity and mortality worldwide. There has been a significant worsening of the obesity epidemic mainly due to alterations in dietary intake and energy expenditure. Alternati...

    Authors: Juliana Austin and Daniel Marks

    Citation: International Journal of Pediatric Endocrinology 2008 2009:141753

    Content type: Review Article

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