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A multicenter study of endocrine abnormalities in septo-optic dysplasia (SOD) in Asean countries


Septo-optic dysplasia (SOD) is a heterogeneous malformation condition consisting of optic nerve hypoplasia, various types of forebrain defects and hormonal deficiencies. This study aims to expand knowledge about endocrine abnormalities in patients with SOD in ASEAN countries.

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Forty-eight patients (27 male, 21 female) who has been diagnosed as having SOD in ASEAN countries were clinically reviewed from medical records.


Clinical manifestations and endocrine abnormalities of the patients are shown in Table 1

Table 1 Clinical manifestation of SOD patients


This multicenter and multinational study shows that about 20-35 % of SOD patients have endocrine abnormalities. Hypothyroidism and GH insufficiency are the most common endocrine problems associated with this condition.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Wacharasindhu, S., Yottasan, P., Jaruratanasirikul, S. et al. A multicenter study of endocrine abnormalities in septo-optic dysplasia (SOD) in Asean countries. Int J Pediatr Endocrinol 2015 (Suppl 1), P85 (2015).

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