Table 1 Clinical manifestation of SOD patients

Age at presentation (months) mean ± SD

33 ± 39 months (range 20 - 178)

MRI findings

Absence of septum pellucidum(%)

62

Ht SDS, mean ± SD

-0.97 ± 1.97

Pituitary hypoplasia (%)

33

Wt SDS, mean ± SD

0.02 ± 2.35

Abnormal of corpus callosum (%)

16

Eye presentation

Nystagmus (%)

54

Cortical dysplasia (%)

8

Squint (%)

3

Endocrine abnormalities

Hypothyroid (%)

35

Poor vision (%)

35

GH insufficiency (%)

29

Delayed development (%)

16.2

Delayed/arrested puberty/suspected HG (%)

23

Seizure (%)

7.9

Cortical insufficiency (%)

17

Hypoglycemia (%)

8.1

Diabetes insipidus (%)

19

Neonatal jaundice (%)

2.7

Eye examination

Unilat ON hypoplasia

13

Undescended testes (%) (boys)

5.4

Bilat ON hypoplasia

84

Micropenis (%) (boys)

21

Microcornea

3