Skip to main content

Increased height standard deviation scores in response to growth hormone therapy to near-adult height in older children with delayed skeletal maturation: results from the ANSWER Program



A primary goal of recombinant human growth hormone therapy (GHT) in children is attaining normal adult height. In this study, children with growth hormone deficiency (GHD) (including isolated idiopathic growth hormone deficiency [IGHD] and multiple pituitary hormone deficiency [MPHD]), idiopathic short stature (ISS), and Turner syndrome (TS) were evaluated for near-adult height (NAH) and percent achieving NAH within the normal range after approximately 4 years of GHT.


Data from the American Norditropin® Studies: Web-Enabled Research (ANSWER) Program were analyzed for NAH from age at treatment start (ATS) (i.e., referral age as defined by age at enrollment in the study) to last clinic visit using one of the following two criteria: 1) age ≥18 years, or 2) if male: ≥16 years and height velocity (HV) <2 cm/year; if female: ≥15 years and HV <2 cm/year. All patients had a baseline height standard deviation score (HSDS) ≤ -2, and either GHD (n = 201), ISS (n = 19), or TS (n = 41). The main outcome measures included HSDS and corrected HSDS (HSDS-target HSDS) in response to GH treatment, and correlation of ATS with NAH HSDS.


Mean (± SD) chronological and bone ages at baseline were 14.0 ± 2.1 years and 11.7 ± 2.0 years, respectively, and mean GHT duration was 4.0 ± 1.6 years. Mean HSDS (baseline to NAH; GHD: -2.7 to -1.0; ISS: -2.8 to -1.4; TS: -3.0 to -1.8) and mean corrected HSDS (baseline to NAH; GHD: -2.1 to -0.3; ISS: -2.1 to -0.6; TS: -1.8 to -0.6) increased across diagnostic indications. Percentages of patients reaching near-adult HSDS > -2 were GHD: 87.6%; ISS: 78.9%; TS: 65.8%. Significant negative correlations were found between ATS and NAH HSDS when analyzed by sex.


Despite a relatively advanced childhood age, the majority of GH-treated patients attained mean near-adult HSDS within the normal range (HSDS > -2). Negative correlations of ATS with near-adult HSDS indicate that an earlier age at treatment start would likely have resulted in greater adult height achieved in both male and female patients.


Treatment with recombinant human growth hormone (GH) is indicated for children with short stature or growth failure associated with a number of conditions in which there is a deficiency of, or decreased responsiveness to, endogenous growth hormone. The use of GH is approved by the US Food and Drug Administration for the treatment of growth failure associated with growth hormone deficiency (GHD), either isolated (IGHD) or part of multiple pituitary hormone deficiency (MPHD), and short stature associated with Turner syndrome (TS), Noonan syndrome (NS), children born small for gestational age (SGA), short stature homeobox (SHOX) gene haploinsufficiency, Prader-Willi syndrome (PWS), chronic kidney disease (CKD), or idiopathic short stature (ISS) [1]. Treatment with GH has been shown to increase short-term linear growth in children with various disorders associated with growth failure; however, some of the short-term clinical studies have shown varying treatment outcomes [24]. A limited number of studies have investigated the effects of long-term GH therapy (GHT) on the adult height standard deviation score (HSDS) achieved and whether the attained adult height was within the normal range.

Attaining adult height within the normal range is an important treatment goal for GHT in children with short stature or growth failure disorders, especially with respect to the potential benefits in health-related quality of life (HRQoL) and physical and psychosocial well-being [5, 6]. The adult height of patients treated with GH is influenced by the height gained during the course of therapy, the rate of bone maturation, and the onset of puberty [7, 8]. Longitudinal analyses of large data sets of pediatric patients have consistently demonstrated that the early initiation and appropriate duration of GH treatment correlated significantly with the achievement of near-normal adult height and greater improvements in HSDS [2, 9, 10]. A multicenter, randomized, double-blind clinical study of children with short stature who were born SGA without signs of catch-up growth showed that GH treatment to adult height was associated with a significant improvement in HRQoL and the normalization of final height [5].

The American Norditropin Studies: Web-Enabled Research (ANSWER) Program (utilizing NovoNet®, the Novo Nordisk Web-based research platform) is an observational, noninterventional study evaluating the long-term effectiveness and safety of Norditropin (somatropin [recombinant DNA origin] injection, Novo Nordisk A/S, Bagsvaerd, Denmark), hereafter referred to as GH, therapy in pediatric and adult patients [11]. Enrollment in this patient registry is solely at the discretion of the participating physicians in patients for whom Norditropin® is prescribed for treatment of appropriate conditions of growth failure and short stature both within and outside the Norditropin® label. Data from the ANSWER Program have shown that children with IGHD, MPHD, ISS, TS, NS, or SGA demonstrated an increase in HSDS from baseline following 2 years of GH treatment [12, 13]. Height velocity (HV) at 4 months of GHT and baseline body mass index (BMI) SDS were significant predictive factors in patients with GHD (including patients with IGHD and MPHD) that positively correlated with a change in HSDS (ΔHSDS) [13]. Baseline age, baseline HSDS, and baseline serum insulin-like growth factor-1 (IGF-I) SDS were negatively correlated with ΔHSDS [12, 13]. No consistent effect of the sex of a patient on response to GH treatment was observed in these analyses from the ANSWER Program; however, a sex-related effect on ΔHSDS was reported by Savendahl et al. [14] in a combined analysis of short-term (2-year) GH treatment responses in children with GHD, MPHD, or SGA enrolled in the ANSWER Program and its European counterpart, the NordiNet® International Outcome Study. Greater growth responses were observed in younger, prepubertal children in all diagnostic groups studied in a report from the ANSWER Program, indicating that early initiation of GH treatment is important for optimizing linear growth response [12].

The principal aim of the current analysis of data from the ANSWER Program registry was to evaluate the effects of GH treatment in previously untreated pediatric patients with GHD, ISS, or TS with baseline HSDS ≤ -2 on near-adult height (NAH) outcomes. The effect of age at the start of treatment on attainment of NAH was also evaluated. NAH was evaluated only at the last clinic visit when GH was discontinued, whereas HSDS was determined at year 1, year 2, and at NAH (i.e., the last clinic visit).


Study design

The ANSWER Program is a non-interventional, observational study initiated in 2002 that has collected long-term effectiveness and safety information on pediatric patients treated with GH. Physicians participating in the ANSWER Program provide updated patient histories and physical examination data utilizing NovoNet®, an online data-reporting tool. Institutional review board (IRB) approval and patient informed consent are obtained before study enrollment, which is at the discretion of participating physician investigators. Pediatric patients were included in the current analyses if they were aged <18 years and GHT-naïve at the time of enrollment, had a baseline HSDS that met criteria for short stature (≤ - 2), and had attained adult height or NAH at their final clinic visit. Height velocity was used as a criterion for near adult height for boys between 16 (inclusive) and 18 years of age and girls between 15 (inclusive) and 18 years of age. In order to calculate height velocity, a height measurement had to have been taken between the minimum interval of 273 and the maximum interval of 548 days before the last visit date. The previous height assessment nearest to 1 year (365 days) prior to the last visit date was used. Height velocity was annualized by calculating the change in height per day and multiplying by 365.25 days. Patients were determined to have reached NAH according to either one of the following two criteria: 1) age at last visit was ≥18 years, or 2) for males <18 years, if their age at last visit was ≥16 years and HV <2 cm/year; or for females < 18 years, if their age at last visit was ≥15 years and HV <2 cm/year. The rationale for using the first NAH criterion of ≥18 years of age was to capture patients who had a limited frequency of clinic visits prior to the last clinic visit that prevented calculation of HV but whose age would be consistent with completion or near completion of statural growth. Patients identified using HV and age criteria had sufficient visit frequency from which to assess HV consistent with NAH. As noted in previous publications from the ANSWER Program pediatric patients are generally excluded from analysis if baseline chronologic age (CA) was <1 year or >18 years, or if baseline values of key variables were missing or deemed inconsistent or implausible (e.g., lack of height information at baseline; baseline height <35 cm or >200 cm; baseline HSDS < -5 or > +2) [13, 15]. The current study assessed children with GHD (patients with IGHD and MPHD), ISS, and TS who reached NAH after treatment with GH. Data were collected from clinic visits within a ±3-month window around each time point (i.e., year 1, year 2, NAH [i.e., last visit]) and growth rates were annualized based on the actual interval between measurements.

Baseline characteristics and measurement of GH treatment effects

Baseline demographics and patient characteristics across all indications in GH-naïve patients were obtained just prior to the start of GH treatment (i.e., at time of enrollment in the registry). Baseline variables at enrollment included sex, CA, bone age (BA), body weight, and height [16]. Other baseline measurements were BA/CA ratio, HSDS, target HSDS, corrected HSDS (HSDS minus target HSDS), predicted HSDS based on predicted adult height calculated using the Bayley-Pinneau method [17], serum levels of IGF-I (ng/mL) and determination of IGF-I SDS, peak stimulated serum GH concentration (ng/mL), BMI (kg/m2), BMI SDS, and initial GH dose (mg/kg/day). At subsequent annual clinic visits, GH dose was reported along with measurements of height, weight, CA, BA, serum IGF-I concentration, and BMI.

Variables and statistical analyses

The following key variables were determined at year 1, year 2, and NAH (i.e., last clinic visit): mean HSDS, mean corrected HSDS, mean change in HSDS (ΔHSDS), BA/CA ratio, IGF-I SDS, and BMI SDS. The percentage of patients who achieved a HSDS at NAH within the normal range (HSDS > -2) was also determined. Height SDS and BMI SDS were calculated using standard reference data developed by the United States Centers for Disease Control and Prevention [18]. Baseline demographic characteristics were summarized using descriptive statistics. Target height was evaluated using the mean height of the patient’s two parents plus 6.5 cm for male patients or minus 6.5 cm for female patients [19]. Corrected HSDS was calculated as the difference between HSDS determined at a given time point and the target HSDS. ΔHSDS was calculated as the difference between the HSDS at baseline and at year 1, year 2, and NAH. All IGF-I values were measured locally and entered into the database. Transformation of IGF-I data into IGF-I SDS was based on the age- and sex-related normative reference values of Brabant et al. [20]. The correlation between age at GH treatment start (ATS) and near-adult HSDS was evaluated by estimating Pearson’s correlation coefficient (R) between the 2 variables. Near-adult HSDS was analyzed using an analysis of covariance model (ANCOVA) with sex as the fixed effect and referral age as the covariate. A regression model was applied to analyze the relationship between ATS (i.e., referral age as defined by age at enrollment in the study) and near-adult HSDS for all patients combined with GHD, ISS, and TS according to sex. Values are reported as mean and standard deviation (±SD) for descriptive statistics or mean and standard error (±SE) for comparative statistics. All differences detected from statistical analyses were considered significant at P values <0.05.


Patient demographics and baseline characteristics

A total of 261 GH-naïve patients who were diagnosed with GHD (n = 201), ISS (n = 19), or TS (n = 41), and had achieved NAH, were included in the analyses. This total patient number consisted of 178 patients identified according to the age criterion (≥18 years) and 83 patients identified according to age and HV criteria for NAH (20 males, 63 females). Demographics and baseline characteristics for the overall study population and for each diagnostic indication cohort are presented in Table 1. Overall, the study population consisted of 173 males (66.3%) and 88 females (33.7%), including 41 females with TS. The mean referral age was 14.7 ± 1.6 years among males and 12.8 ± 2.3 years among females. The mean ± SD baseline CA across all indications (N = 261) was 14.0 ± 2.1 years (14.9 ± 1.5 years among patients identified according to the age criterion, 12.7 ± 1.9 years among male patients identified according to the HV criterion, and 12.2 ± 2.1 years among female patients identified according to the HV criterion). Mean ± SD BA across indications at baseline was 11.7 ± 2.0 years (N = 215), approximately 2 years behind CA; this was also reflected in a baseline BA/CA ratio <1 across all patient cohorts (0.85 ± 0.08, N = 215).

Table 1 Baseline demographics, characteristics, and GH treatment duration

At baseline (Table 1), the mean ± SD stimulated peak serum GH concentration (ng/mL) was 5.5 ± 2.8 in patients with GHD, 20.3 ± 9.7 in patients with ISS, and 10.9 ± 8.7 in females with TS. Mean ± SD IGF-I SDS was -2.7 ± 1.60 in patients with GHD, -2.3 ± 1.81 in those with ISS, and -1.7 ± 1.22 in females with TS.

The mean ± SD duration in years of GH treatment by indication (Table 1) was 3.9 ± 1.5 for both GHD and ISS groups, and 4.4 ± 2.0 in females with TS. The mean initial GH doses (mg/kg/d) administered to each patient cohort at treatment start (Table 1) were 0.047 ± 0.013 (n = 199) in patients with GHD, 0.050 ± 0.006 (n = 19) in those with ISS, and 0.052 ± 0.008 (n = 41) in females with TS.

Analysis of auxological measurements

Height standard deviation scores

The mean ± SD baseline HSDS was -3.0 ± 0.6 (n = 41) for patients with TS, -2.8 ± 0.6 (n = 19) for patients with ISS, and -2.7 ± 0.5 (n = 201) for patients with GHD. Target HSDS (mean ± SD) at baseline was -0.7 ± 0.7 (n = 18) for patients with ISS, -0.3 ± 0.8 (n = 171) for patients with GHD, and +0.2 ± 0.9 (n = 33) for patients with TS (Table 1). Mean ± SE HSDS gradually increased over time for the overall study population from -2.8 ± 0.04 (n = 261) at baseline to -1.1 ± 0.06 (n = 261) at NAH (Figure 1A). Patients with GHD, ISS, and TS experienced increases in mean ± SE HSDS from baseline to NAH (near-adult HSDS: GHD, -1.0 ± 0.065, n = 201; ISS, -1.4 ± 0.210, n = 19; TS, -1.8 ± 0.118, n = 41). Both mean ± SE ΔHSDS (Figure 1B) and mean ± SE corrected HSDS (Figure 1C) increased with GH treatment (ΔHSDS at NAH: GHD, 1.74 ± 0.06, n = 201; ISS, 1.45 ± 0.19, n = 19; TS, 1.19 ± 0.10, n = 41; baseline corrected HSDS: GHD, -2.1 ± 0.31, n = 169; ISS, -2.1 ± 0.16, n = 18; TS, -1.8 ± 0.92, n = 34; corrected HSDS at NAH: GHD, -0.3 ± 0.31, n = 169; ISS, -0.6 ± 0.23, n = 18; TS, -0.6 ± 0.96, n = 34). The mean ± SD GH dose (mg/kg/d) at NAH for each cohort across indications (GHD: 0.050 ± 0.018, n = 199; ISS: 0.052 ± 0.012, n = 19; and TS: 0.053 ± 0.011, n = 41) had not changed markedly from treatment start. The majority of patients in each indication achieved heights in the normal range (> - 2 HSDS) by the last visit: 87.6%, 78.9%, and 65.8% of GHD, ISS and TS patients, respectively (83.5% of patients overall).

Figure 1
figure 1

HSDS, ΔHSDS and corrected HSDS in patients from baseline to near-adult height at the last visit. (A) Mean HSDS at baseline, year 1, year 2, and NAH at the last clinic visit. (B) Mean ΔHSDS (HSDS-target HSDS) at year 1, year 2, and NAH at the last visit. (C) Mean corrected HSDS at baseline, year 1, year 2, and NAH at the last visit. GHD: growth hormone deficiency; HSDS: height standard deviation score; ISS: idiopathic short stature; NAH: near-adult height; TS: Turner syndrome.

Age at treatment start and near-adult HSDS

When evaluating the total patient population, no significant correlation was found between ATS and near-adult HSDS (Pearson’s correlation coefficient, R = -0.072, P = 0.25). The ANCOVA model with sex as the fixed effect and referral age as the covariate confirmed that sex (P < 0.001) and referral age (P < 0.001) were statistically significant, indicating a relationship between near-adult HSDS, referral age and sex. When analyzing this relationship separately by patient sex, significant negative correlations were found for both males and females (including patients with TS): males, Pearson’s correlation coefficient, R = -0.21, P = 0.006; females, Pearson’s correlation coefficient, R = -0.25, P = 0.017 (Figure 2).

Figure 2
figure 2

Effects of age at treatment start on adult HSDS by sex. Correlation between ATS and adult HSDS (P < 0.001). The effects of ATS on adult HSDS vary depending on sex (P < 0.001; ANCOVA). ATS: age at treatment start; HSDS: height standard deviation score. Top line: Regression of near-adult HSDS against ATS for males. Bottom line: Regression of near-adult HSDS against ATS for females.


The attainment of NAH across patient cohorts was paralleled by increases in mean ± SE IGF-I SDS (Figure 3A) to within the normal reference range across all indications (GHD at baseline: -2.74 ± 0.130, n = 152; GHD at NAH: 0.27 ± 0.172, n = 193; ISS at baseline: -2.29 ± 0.522, n = 12; ISS at NAH: 0.15 ± 0.687, n = 16; TS at baseline: -1.72 ± 0.255, n = 23; TS at NAH, 1.05 ± 0.333, n = 35). Mean ± SE BMI SDS (Figure 3B) showed minimal change for each indication over time during GH treatment (GHD at baseline: -0.32 ± 0.101, n = 201; GHD at NAH: -0.11 ± 0.097, n = 201; ISS at baseline: -0.68 ± 0.246, n = 18; ISS at NAH: -0.20 ± 0.230, n = 19; TS at baseline: 0.53 ± 0.141, n = 41; TS at NAH: 0.66 ± 0.135, n = 41). Mean ± SE BA/CA ratio remained stable over time during GH treatment across all indications (GHD at baseline: 0.85 ± 0.006, n = 169; GHD at NAH: 0.86 ± 0.006, n = 197; ISS at baseline: 0.84 ± 0.019, n = 16; ISS at NAH: 0.88 ± 0.021, n = 19; TS at baseline: 0.84 ± 0.016, n = 30; TS at NAH: 0.82 ± 0.014, n = 39).

Figure 3
figure 3

IGF-I SDS and BMI SDS from baseline to near-adult height at the last visit. (A) IGF-I SDS at baseline, year 1, year 2, and NAH at the last clinic visit. (B) BMI SDS at baseline, year 1, year 2, and NAH at the last visit. BMI: body mass index; GHD: growth hormone deficiency; IGF-1: insulin-like growth factor-1; ISS: idiopathic short stature; NAH: near-adult height; SDS: standard deviation score; TS: Turner syndrome. Error bars represent standard error (SE).


The results of this analysis of GH treatment in pediatric patients with GHD, ISS, or TS demonstrated that GH-naïve children with short stature achieved a mean NAH within the normal reference range. Mean HSDS, corrected HSDS, and IGF-I SDS all improved over time with GH treatment, and the majority of patients were within the normal reference range (> - 2 HSDS) at the time of NAH. Overall, 83.5% of the study population had attained normal height (HSDS > -2) over the duration of GH treatment (mean duration, years: GHD 3.9; ISS 3.9; TS 4.4). It is possible that the results were biased towards good responders, since poor responders may have withdrawn from the study or stopped GH treatment before reaching adulthood. The proportion of TS patients who attained normal height (66%) in this study was smaller compared with those of the other indications studied (79-88%). The reasons for this finding are unclear; nevertheless, this result is consistent with findings from a previous analysis of patients with TS from the ANSWER program [21].

At baseline, the mean ± SD overall age was 14.0 ± 2.1 years (12.8 years in females and 14.7 years in males), which was nearly 4 years older than the mean age of pediatric patients typically enrolled in the ANSWER Program (10.5 ± 4.0 years). Consequently, this analysis of patients who attained NAH was skewed toward children who were older at the time of GHT initiation, and thus may not be representative of the overall population in the ANSWER Program. The short duration of the Program (initiated in 2002) could have contributed to a selection bias towards older patients since a substantial proportion of enrolled patients would not have reached 18 years as of the cut-off date for this current analysis. The older age at baseline in this subgroup may have resulted in an underestimation of the overall adult height achievable by all patients treated with GH. Previous studies from the ANSWER Program have shown that earlier age at GH treatment initiation is associated with greater height gain [12, 13], reinforcing the importance of early referral for GHT in appropriate patients when growth failure or short stature is recognized. From the results of this analysis of the changes in mean HSDS and corrected HSDS from baseline to NAH, it would appear that these patients did experience a beneficial response to GH treatment. Sex was confirmed to be a statistically significant factor for NAH outcome, possibly due to the difference in referral age between sexes (females were younger than males). The significant negative correlation observed between ATS and near-adult HSDS for both sex subgroups indicates that, although a beneficial effect may be observed when GH therapy is initiated at an older childhood age, greater near-adult HSDS can be expected if these patients had started GHT at a younger age. Healthcare providers should therefore be aware of the potential limitations of this treatment among patients of a relatively advanced age. The correlation results of this study in relatively older children are consistent with recently published analyses of GH treatment on increasing linear growth to NAH or final height in younger children with IGHD or MPHD from other large patient databases [2226]. This has also been shown in patients from other diagnostic groups, such as Noonan syndrome. Recently published ANSWER Program data on patients with Noonan syndrome with a mean referral age of 9 years showed that baseline age was negatively correlated with ΔHSDS after 1 or 2 years of GH treatment, indicating that older baseline ATS resulted in lower ΔHSDS [2729]. In the present study, analysis of the relationship between age at initiation of GHT and near-adult HSDS in patients with GHD, ISS, and TS showed significant negative correlations, which is consistent with previous reports [13, 15, 28]. The results of the current analysis are among the first to describe the long-term effects of GH treatment, including an increase in HSDS at the time of NAH, in children who initiated GHT at an older age.

The effect of GH treatment on the BA/CA ratio was relatively small, and BA/CA remained <1 for patients across all indications over time. This suggests that, although GH treatment exerted positive effects on linear growth in this older pediatric patient population, there was a minimal effect on bone maturation relative to CA. The effect of pubertal stage in these patients was not analyzed and cannot be ruled out as a contributing factor. Also, the mean BA/CA ratio in the range of 0.82 to 0.88 indicates that, on average, a small amount of additional growth would have remained in some patients, consistent with near rather than final peak adult height.

Mean IGF-I SDS increased in patients with GHD, ISS, and TS at year 1 of GH treatment, remaining relatively stable thereafter. The difference in mean IGF-I SDS (GHD - ISS) was only -0.45 at baseline and 0.12 at NAH. From baseline to NAH, BMI SDS showed variable increases, but remained stable, during GHT among the diagnostic groups. This occurred in parallel with sustained increases in HSDS and corrected HSDS in each group during GH treatment. The negative mean BMI SDS at baseline observed in patients with ISS in the present study might suggest a degree of relative nutritional deficiency in these individuals that improved over time. Recent results published from the ANSWER Program registry indicated that for patients with GHD, a higher baseline BMI was positively correlated with the response to GH [13]. The association of BMI on GH response may reflect, in part, the importance of nutrition or nutritional status for optimizing outcomes in GH-treated patients [12, 13, 30, 31].


In conclusion, long-term GH therapy in GH-naïve pediatric patients with GHD, ISS, or TS resulted in increases in HSDS and corrected HSDS from baseline to NAH despite their older age at the start of GHT. Although the results of this study demonstrate good NAH outcomes in children with short stature or growth failure who initiated GH treatment at an older age, the negative correlations of ATS with near-adult HSDS when analyzed by sex indicate that earlier recognition and referral for growth failure or short stature, and efforts to start GH treatment at a younger age, would most likely have resulted in greater gains in height and an increase in adult HSDS.



Age at treatment start


Bone age


Body mass index


Chronological age


Growth hormone


Growth hormone deficiency


Growth hormone therapy


Height standard deviation score


Height velocity


Insulin-like growth factor-1


Isolated idiopathic growth hormone deficiency


Idiopathic short stature


Multiple pituitary hormone deficiency


Near-adult height


Standard deviation score


Turner syndrome.


  1. Richmond E, Rogol AD: Current indications for growth hormone therapy for children and adolescents.Endocr Dev 2010, 18:92–108.

    Article  CAS  PubMed  Google Scholar 

  2. Romano AA, Dana K, Bakker B, Davis DA, Hunold JJ, Jacobs J, et al.: Growth response, near-adult height, and patterns of growth and puberty in patients with noonan syndrome treated with growth hormone.J Clin Endocrinol Metab 2009, 94:2338–44. 10.1210/jc.2008-2094

    Article  CAS  PubMed  Google Scholar 

  3. Sas TC, de Ridder MA, Wit JM, Rotteveel J, Oostdijk W, Reeser HM, et al.: Adult height in children with growth hormone deficiency: a randomized, controlled, growth hormone dose–response trial.Horm Res Paediatr 2010, 74:172–81. 10.1159/000281323

    Article  CAS  PubMed  Google Scholar 

  4. Albertsson-Wikland K, Aronson AS, Gustafsson J, Hagenas L, Ivarsson SA, Jonsson B, et al.: Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency.J Clin Endocrinol Metab 2008, 93:4342–50. 10.1210/jc.2008-0707

    Article  CAS  PubMed  Google Scholar 

  5. Bannink E, Djurhuus CB, Christensen T, Jons K, Hokken-Koelega A: Adult height and health-related quality of life after growth hormone therapy in small for gestational age subjects.J Med Econ 2010, 13:221–7. 10.3111/13696998.2010.484323

    Article  CAS  PubMed  Google Scholar 

  6. Deodati A, Cianfarani S: Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review.BMJ 2011, 342:c7157. 10.1136/bmj.c7157

    Article  PubMed  Google Scholar 

  7. Cohen P, Bright GM, Rogol AD, Kappelgaard AM, Rosenfeld RG: Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety.J Clin Endocrinol Metab 2002, 87:90–8. 10.1210/jcem.87.1.8150

    Article  CAS  PubMed  Google Scholar 

  8. Crowe BJ, Rekers-Mombarg LT, Robling K, Wolka AM, Cutler GB Jr, Wit JM: Effect of growth hormone dose on bone maturation and puberty in children with idiopathic short stature.J Clin Endocrinol Metab 2006, 91:169–75. 10.1210/jc.2005-0891

    Article  CAS  PubMed  Google Scholar 

  9. de Ridder MA, Stijnen T, Hokken-Koelega AC: Prediction of adult height in growth-hormone-treated children with growth hormone deficiency.J Clin Endocrinol Metab 2007, 92:925–31. 10.1210/jc.2006-1259

    Article  CAS  PubMed  Google Scholar 

  10. Carel JC, Ecosse E, Nicolino M, Tauber M, Leger J, Cabrol S, et al.: Adult height after long term treatment with recombinant growth hormone for idiopathic isolated growth hormone deficiency: observational follow up study of the French population based registry.BMJ 2002, 325:70. 10.1136/bmj.325.7355.70

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hoybye C, Savendahl L, Christesen HT, Lee P, Pedersen BT, Schlumpf M, et al.: The NordiNet(R) International Outcome Study and NovoNet(R) ANSWER Program(R): rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Norditropin(R)).Clin Epidemiol 2013, 5:119–27.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Ross J, Czernichow P, Biller BM, Colao A, Reiter E, Kiess W: Growth hormone: health considerations beyond height gain.Pediatrics 2010, 125:e906–18. 10.1542/peds.2009-1783

    Article  PubMed  Google Scholar 

  13. Lee PA, Germak J, Gut R, Khutoryansky N, Ross J: Identification of factors associated with good response to growth hormone therapy in children with short stature: results from the ANSWER Program.Int J Pediatr Endocrinol 2011, 2011:6. 10.1186/1687-9856-2011-6

    Article  PubMed  PubMed Central  Google Scholar 

  14. Savendahl L, Blankenstein O, Oliver I, Christesen HT, Lee P, Pedersen BT, et al.: Gender influences short-term growth hormone treatment response in children.Horm Res Paediatr 2012, 77:188–94. 10.1159/000337570

    Article  PubMed  Google Scholar 

  15. Ross J, Lee PA, Gut R, Germak J: Factors influencing the one- and two-year growth response in children treated with growth hormone: analysis from an observational study.Int J Pediatr Endocrinol 2010, 2010:494656. 10.1186/1687-9856-2010-494656

    Article  PubMed  PubMed Central  Google Scholar 

  16. Lee PA, Houk CP: Puberty and its disorders. In Pediatric endocrinology. 5th edition. Edited by: Lifshitz F. New York, NY: Informa Healthcare; 2007:273–303.

    Google Scholar 

  17. Bayley N, Pinneau SR: Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards.J Pediatr 1952, 40:423–41. 10.1016/S0022-3476(52)80205-7

    Article  CAS  PubMed  Google Scholar 

  18. Percentile data files with LMS values. []

  19. Attanasio AF, Howell S, Bates PC, Frewer P, Chipman J, Blum WF, et al.: Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-deficient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients.J Clin Endocrinol Metab 2002, 87:3368–72. 10.1210/jcem.87.7.8593

    Article  CAS  PubMed  Google Scholar 

  20. Brabant G, von zur Muhlen A, Wuster C, Ranke MB, Kratzsch J, Kiess W, et al.: Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study.Horm Res 2003, 60:53–60. 10.1159/000071871

    CAS  PubMed  Google Scholar 

  21. Ross J, Lee PA, Gut R, Germak J: Impact of age and duration of growth hormone therapy in children with Turner syndrome.Horm Res Paediatr 2011, 76:392–9. 10.1159/000333073

    Article  CAS  PubMed  Google Scholar 

  22. Reiter EO, Price DA, Wilton P, Albertsson-Wikland K, Ranke MB: Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database.J Clin Endocrinol Metab 2006, 91:2047–54. 10.1210/jc.2005-2284

    Article  CAS  PubMed  Google Scholar 

  23. Darendeliler F, Lindberg A, Wilton P: Response to growth hormone treatment in isolated growth hormone deficiency versus multiple pituitary hormone deficiency.Horm Res Paediatr 2011,76(Suppl 1):42–6.

    Article  CAS  PubMed  Google Scholar 

  24. Root AW, Dana K, Lippe B: Treatment of growth hormone-deficient infants with recombinant human growth hormone to near-adult height: patterns of growth.Horm Res Paediatr 2011, 75:276–83. 10.1159/000322881

    Article  CAS  PubMed  Google Scholar 

  25. Ranke MB, Lindberg A: Observed and predicted total pubertal growth during treatment with growth hormone in adolescents with idiopathic growth hormone deficiency, Turner syndrome, short stature, born small for gestational age and idiopathic short stature: KIGS analysis and review.Horm Res Paediatr 2011, 75:423–32. 10.1159/000324117

    Article  CAS  PubMed  Google Scholar 

  26. Ranke MB, Lindberg A, Price DA, Darendeliler F, Albertsson-Wikland K, Wilton P, et al.: Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature.Horm Res 2007, 68:53–62. 10.1159/000098707

    CAS  PubMed  Google Scholar 

  27. Hamill PV, Drizd TA, Johnson CL, Reed RB, Roche AF, Moore WM: Physical growth: National Center for Health Statistics percentiles.Am J Clin Nutr 1979, 32:607–29.

    CAS  PubMed  Google Scholar 

  28. Rosenfeld RG, Bakker B: Compliance and persistence in pediatric and adult patients receiving growth hormone therapy.Endocr Pract 2008, 14:143–54. 10.4158/EP.14.2.143

    Article  PubMed  Google Scholar 

  29. Lee PA, Ross J, Germak JA, Gut R: Effect of 4 years of growth hormone therapy in children with Noonan syndrome in the American norditropin studies: web-enabled research (ANSWER) program(R) registry.Int J Pediatr Endocrinol 2012, 2012:15. 10.1186/1687-9856-2012-15

    Article  PubMed  PubMed Central  Google Scholar 

  30. Grumbach MM, Bin-Abbas BS, Kaplan SL: The growth hormone cascade: progress and long-term results of growth hormone treatment in growth hormone deficiency.Horm Res 1998,49(Suppl 2):41–57.

    Article  CAS  Google Scholar 

  31. Farber RS, Kerrigan JR: The multiple indications for growth hormone treatment of pediatric patients.Pediatr Ann 2006, 35:926–32.

    PubMed  Google Scholar 

Download references


Editorial and writing assistance were provided by Jeffrey M. Palmer, PhD, ETHOS Health Communications, Newtown, Pennsylvania, with financial assistance from Novo Nordisk Inc, Plainsboro, New Jersey, in compliance with international guidelines on Good Publication Practice.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Judith L Ross.

Additional information

Competing interests

Judith L. Ross, MD, is a consultant for Novo Nordisk and Eli Lilly, and receives research support from Novo Nordisk, and Eli Lilly.

Peter A. Lee, MD, PhD, is a consultant for Novo Nordisk, Abbvie, and Ipsen, and receives research support from Pfizer, Novo Nordisk, Eli Lilly, Tercica, and Abbvie.

Robert Gut, MD, PhD is an employee of Novo Nordisk, Inc.

John Germak, MD, is an employee of Novo Nordisk, Inc.

Authors’ contributions

All authors made substantial contributions to the study design and interpretation, critically revised the manuscript, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ross, J.L., Lee, P.A., Gut, R. et al. Increased height standard deviation scores in response to growth hormone therapy to near-adult height in older children with delayed skeletal maturation: results from the ANSWER Program. Int J Pediatr Endocrinol 2015, 1 (2015).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: