Characteristic | Overall | GHD | ISS | TS | ||||
---|---|---|---|---|---|---|---|---|
(N = 261) | (n = 201) | (n = 19) | (n = 41) | |||||
N | Mean ± SD | N | Mean ± SD | N | Mean ± SD | N | Mean ± SD | |
Sex, M/F | 173/88 | 158/43 | 15/4 | 0/41 | ||||
Chronologic age (CA), y | ||||||||
All NAH criteria | 261 | 14.0 ± 2.1 | 201 | 14.2 ± 1.9 | 19 | 14.0 ± 1.9 | 41 | 13.1 ± 2.5 |
age >18 y | 178 | 14.9 ± 1.5 | 149 | 14.9 ± 1.5 | 13 | 14.6 ± 1.4 | 16 | 14.9 ± 2.2 |
male, age >16 y, | 20 | 12.7 ± 1.9 | 18 | 12.5 ± 1.9 | 2 | 14.6 ± 0.06 | - | - |
HV < 2 cm/y | ||||||||
female, age >15 y, HV <2 cm/y | 63 | 12.2 ± 2.1 | 34 | 12.4 ± 2.1 | 4 | 11.9 ± 2.3 | 25 | 11.9 ± 2.0 |
Bone age (BA), y | 215 | 11.7 ± 2.0 | 169 | 11.9 ± 1.9 | 16 | 11.6 ± 2.2 | 30 | 11.0 ± 2.2 |
BA/CA ratio | 215 | 0.85 ± 0.08 | 169 | 0.85 ± 0.08 | 16 | 0.84 ± 0.08 | 30 | 0.84 ± 0.09 |
HSDS | ||||||||
All NAH criteria | 261 | -2.8 ± 0.6 | 201 | -2.7 ± 0.5 | 19 | -2.8 ± 0.6 | 41 | -3.0 ± 0.6 |
age >18 y | 178 | -2.8 ± 0.6 | 149 | -2.7 ± 0.6 | 13 | -2.9 ± 0.7 | 16 | -2.9 ± 0.7 |
male, age >16 y, HV < 2 cm/y | 20 | -2.5 ± 0.4 | 18 | -2.5 ± 0.4 | 2 | -2.6 ± 0.0 | - | - |
female, age >15 y, HV <2 cm/y | 63 | -2.8 ± 0.5 | 34 | -2.7 ± 0.5 | 4 | -2.6 ± 0.3 | 25 | -3.0 ± 0.6 |
Target HSDS | 222 | -0.3 ± 0.8 | 171 | -0.3 ± 0.8 | 18 | -0.7 ± 0.7 | 33 | 0.2 ± 0.9 |
Corrected HSDS | 221 | -2.1 ± 4.1 | 169 | -2.1 ± 4.0 | 18 | -2.1 ± 0.7 | 34 | -1.8 ± 5.3 |
Predicted HSDS* | 186 | -1.4 ± 1.1 | 143 | -1.2 ± 1.0 | 13 | -1.6 ± 1.1 | 30 | -2.1 ± 0.9 |
IGF-I SDS | 187 | -2.6 ± 1.60 | 152 | -2.7 ± 1.60 | 12 | -2.3 ± 1.81 | 23 | -1.7 ± 1.22 |
BMI, kg/m2 | 260 | 19.9 ± 4.5 | 201 | 19.7 ± 4.5 | 18 | 18.1 ± 2.8 | 41 | 21.4 ± 4.9 |
BMI SDS | 260 | -0.21 ± 1.38 | 201 | -0.32 ± 1.44 | 18 | -0.68 ± 1.05 | 41 | 0.53 ± 0.90 |
Peak GH, ng/mL | 166 | 6.9 ± 5.7 | 148 | 5.5 ± 2.8 | 14 | 20.3 ± 9.7 | 4 | 10.9 ± 8.7 |
Initial GH dose, mg/kg/d | 259 | 0.048 ± 0.012 | 199 | 0.047 ± 0.013 | 19 | 0.050 ± 0.006 | 41 | 0.052 ± 0.008 |
Treatment duration, y | 261 | 4.0 ± 1.6 | 201 | 3.9 ± 1.5 | 19 | 3.9 ± 1.5 | 41 | 4.4 ± 2.0 |