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Table 1 Baseline demographics, characteristics, and GH treatment duration

From: Increased height standard deviation scores in response to growth hormone therapy to near-adult height in older children with delayed skeletal maturation: results from the ANSWER Program

Characteristic Overall GHD ISS TS
  (N = 261) (n = 201) (n = 19) (n = 41)
  N Mean ± SD N Mean ± SD N Mean ± SD N Mean ± SD
Sex, M/F 173/88   158/43   15/4   0/41  
Chronologic age (CA), y         
   All NAH criteria 261 14.0 ± 2.1 201 14.2 ± 1.9 19 14.0 ± 1.9 41 13.1 ± 2.5
   age >18 y 178 14.9 ± 1.5 149 14.9 ± 1.5 13 14.6 ± 1.4 16 14.9 ± 2.2
   male, age >16 y, 20 12.7 ± 1.9 18 12.5 ± 1.9 2 14.6 ± 0.06 - -
   HV < 2 cm/y         
   female, age >15 y, HV <2 cm/y 63 12.2 ± 2.1 34 12.4 ± 2.1 4 11.9 ± 2.3 25 11.9 ± 2.0
Bone age (BA), y 215 11.7 ± 2.0 169 11.9 ± 1.9 16 11.6 ± 2.2 30 11.0 ± 2.2
BA/CA ratio 215 0.85 ± 0.08 169 0.85 ± 0.08 16 0.84 ± 0.08 30 0.84 ± 0.09
HSDS         
   All NAH criteria 261 -2.8 ± 0.6 201 -2.7 ± 0.5 19 -2.8 ± 0.6 41 -3.0 ± 0.6
   age >18 y 178 -2.8 ± 0.6 149 -2.7 ± 0.6 13 -2.9 ± 0.7 16 -2.9 ± 0.7
   male, age >16 y, HV < 2 cm/y 20 -2.5 ± 0.4 18 -2.5 ± 0.4 2 -2.6 ± 0.0 - -
   female, age >15 y, HV <2 cm/y 63 -2.8 ± 0.5 34 -2.7 ± 0.5 4 -2.6 ± 0.3 25 -3.0 ± 0.6
Target HSDS 222 -0.3 ± 0.8 171 -0.3 ± 0.8 18 -0.7 ± 0.7 33 0.2 ± 0.9
Corrected HSDS 221 -2.1 ± 4.1 169 -2.1 ± 4.0 18 -2.1 ± 0.7 34 -1.8 ± 5.3
Predicted HSDS* 186 -1.4 ± 1.1 143 -1.2 ± 1.0 13 -1.6 ± 1.1 30 -2.1 ± 0.9
IGF-I SDS 187 -2.6 ± 1.60 152 -2.7 ± 1.60 12 -2.3 ± 1.81 23 -1.7 ± 1.22
BMI, kg/m2 260 19.9 ± 4.5 201 19.7 ± 4.5 18 18.1 ± 2.8 41 21.4 ± 4.9
BMI SDS 260 -0.21 ± 1.38 201 -0.32 ± 1.44 18 -0.68 ± 1.05 41 0.53 ± 0.90
Peak GH, ng/mL 166 6.9 ± 5.7 148 5.5 ± 2.8 14 20.3 ± 9.7 4 10.9 ± 8.7
Initial GH dose, mg/kg/d 259 0.048 ± 0.012 199 0.047 ± 0.013 19 0.050 ± 0.006 41 0.052 ± 0.008
Treatment duration, y 261 4.0 ± 1.6 201 3.9 ± 1.5 19 3.9 ± 1.5 41 4.4 ± 2.0
  1. Abbreviations: BMI body mass index, GH growth hormone, GHD growth hormone deficiency, HSDS height standard deviation score, IGF-I insulin-like growth factor-1, ISS idiopathic short stature, M/F male/female, TS Turner syndrome, SDS standard deviation score; y, years.
  2. Predicted HSDS was calculated by the Bayley-Pinneau method [17] using a child’s current height, sex, chronological age, and bone age.