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  • Open Access

Prevalence of thyroid disorders among children with Down syndrome seen in the out-patient clinics of the Philippine general hospital

  • 1 and
  • 1
International Journal of Pediatric Endocrinology20152015 (Suppl 1) :P101

  • Published:


  • Hypothyroidism
  • Congenital Heart Disease
  • Congenital Heart
  • Down Syndrome
  • Hyperthyroidism


Thyroid disorders are noted to occur in 28–40% of children with Down syndrome [1]. Hypothyroidism has a subtle presentation and can be particularly challenging to detect in patients with intellectual disabilities and communication and language impairments [2]. Regular screening and early diagnosis of thyroid disorders, particularly hypothyroidism, is essential for early intervention.


To determine the prevalence of thyroid disorders among children with Down Syndrome (DS) seen in the outpatient clinics of the Philippine General Hospital from January 2007 to December 2011.

Secondary objectives

To classify the thyroid disorders present; to describe the clinical profiles and genotype of the children with Down syndrome.


A Retrospective chart review of all patients with Down syndrome seen in the Out-patient Clinics of the Philippine General Hospital from January 2007 to December 2011.


Eighty-nine patients were included, 60% males and 40% females .Fifty-six percent had thyroid disorders. Of these, eighty percent had subclinical hypothyroidism, 12% had overt hypothyroidism, while 8% had hyperthyroidism. The mean age for the diagnosis of thyroid disorder was 3.33 (±0.52) years old. The mean age on initial consult was 2.38 (±3.14) years. The mean age of mothers at childbirth was 34.23 (±6.77) years. The most common co-morbid illness was congenital heart disease (46%, 41/89). The most common chromosomal abnormality was full trisomy 21 (95.51%, 85/89).


Fifty-six percent of children with Down syndrome in this study have thyroid disorders, with subclinical hypothyroidism being the most common. This study provides evidence for the need of regular monitoring of thyroid function test among children with DS.

Authors’ Affiliations

Philippine General Hospital, Manila, Philippines


  1. Weijerman M, de Winter J P: Clinical practice. The care of children with Down syndrome. Eur J Pediatr. 2010, 169: 1445-1452. 10.1007/s00431-010-1253-0.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Carroll K, et al: Increase in Incidence of Medically Treated Thyroid Disease in Children With Down Syndrome After Rerelease of American Academy of Pediatrics Health Supervision Guidelines. PEDIATRICS. 2008, 122 (2): e493-e498. 10.1542/peds.2007-3252.PubMed CentralView ArticlePubMedGoogle Scholar


© Matitu-Untalan and Estrada; licensee BioMed Central Ltd. 2015

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