Table 1 Study outcomes in the offspring (adults, F1) born from mothers who were either treated with antenatal betamethasone (Steroid) or not treated (Control), and in subsequent generation (children, F2). Data are means and 95% CI, adjusted for confounders.
| Â | Â | Steroid | Control | p-value |
|---|---|---|---|---|
Adults (F1) | n | 23 | 29 | Â |
|  | 1st phase insulin (mU/l) | 43.1 (30.9–60.2) | 28.1 (20.9–37.8) | 0.031 |
|  | 2nd phase insulin (mU/l) | 57.5 (42.6–77.8) | 41.6 (31.8–54.4) | 0.068 |
|  | Total insulin (mU/l) | 101.7 (74.7–138.4) | 70.4 (53.5–92.6) | 0.044 |
|  | Insulin sensitivity | 16.1 (11.0–22.4) | 23.1 (17.3–30.2) | 0.061 |
|  | Insulin sensitivity last 60 min | 14.3 (9.9–19.7) | 20.6 (15.7–26.6) | 0.048 |
Children (F2) | n | 30 | 31 | Â |
|  | Fasting glucose (mg/dl) | 4.88 (4.69–5.12) | 4.67 (4.50–4.85) | 0.049 |
|  | Fasting insulin (mU/l) | 5.05 (3.98–6.41) | 3.57 (2.79–4.58) | 0.008 |
|  | HOMA-IR | 1.10 (0.85–1.43) | 0.74 (0.57–0.98) | 0.006 |