Van Wyk-Grumbach syndrome in a female pediatric patient with trisomy 21: a case report

Table 1 Review of laboratory evaluation over the clinical course of treatment with Levothyroxine

Laboratory parameter	Normal range	At time of diagnosis	1 month after treatment	2 months after treatment	9 months after treatment
TSH	0.54–4.53 mIU/mL	> 150	43.5	9.2	1.3
Free T4	0.85–1.75 ng/dL	0.3	1.2	1.6	1.4
Total T4	7.3–15.0 mcg/dL	< 0.3			9.4
TPO antibodies	0.0–9.0 IU/mL	1763.0
Tg antibodies	0.0–4.0 IU/mL	85.2
LH	3–7 years: < or = 0.26 mIU/mL	< 0.02
FSH	0–4 years: Not established 5–9 years: 0.72–5.33 mIU/mL	12.64
Estradiol, 17 beta	Tanner I < 25 pg/mL	154.0	18.6	< 1.0
Testosterone total	Prepubertal Females: < 2.5–10 ng/ dL	< 2.5
AFP	<=8.1 ng/mL	31.0	12.2	2.9

TSH thyroid stimulating hormone, T4 thyroxine, TPO thyroid Peroxidase, Tg thyroglobulin, LH luteinizing hormone, FSH follicle stimulating hormone, AFP alpha-fetoprotein

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