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Table 2 Demographic characteristics of patients for BMI SDS analysisa

From: Outcomes in children treated with growth hormone for Prader-Willi syndrome: data from the ANSWER Program® and NordiNet® International Outcome Study

Variable

ANSWER Program®

NordiNet® IOS

All

Age at GH start, years

n = 39

n = 59

n = 98

Mean (SD)

7.95 (4.21)

3.98 (4.52)

5.56 (4.79)

Median (range)

7.85 (2.04–17.56)

1.92 (0.39–17.66)

3.44 (0.39–17.66)

Female, %

62%

41%

49%

Baseline BA/CA ratiob

n = 13

1.06 (0.17)

n = 13

0.79 (0.31)

n = 26

0.92 (0.28)

Final BA/CA ratiob

n = 21

1.07 (0.17)

n = 27

0.88 (0.17)

n = 48

0.97 (0.19)

GH baseline dose, mg/kg/d

n = 39

0.03 (0.01)

n = 59

0.03 (0.01)

n = 98

0.03 (0.01)

GH final dose, mg/kg/db

n = 35

0.03 (0.01)

n = 56

0.03 (0.01)

n = 91

0.03 (0.01)

IGF-I SDSb

n = 19

−0.46 (2.01)

n = 35

−0.87 (1.71)

n = 54

−0.72 (1.81)

Weight, kg

n = 39

38.89 (24.75)

n = 59

17.84 (18.61)

n = 98

26.21 (23.54)

Baseline height, cm

n = 39

119.6 (25.24)

n = 59

89.68 (28.29)

n = 98

101.6 (30.73)

Last recorded height, cm

n = 39

140.3 (21.25)

n = 59

122.4 (27.55)

n = 98

129.6 (26.61)

BMI, kg/m2

n = 39

24.68 (7.75)

n = 59

18.04 (4.90)

n = 98

20.68 (6.97)

Baseline BMI SDS

n = 39

1.80 (1.68)

n = 59

0.40 (1.54)

n = 98

0.96 (1.73)

Final BMI SDS

n = 39

1.88 (0.91)

n = 59

0.98 (1.83)

n = 98

1.34 (1.59)

Years of follow-up

n = 39

n = 59

n = 98

Mean (SD)

2.28 (1.34)

2.56 (1.30)

2.45 (1.32)

Median (range)

2.25 (0.06, 3.93)

3.09 (0.16, 3.98)

2.54 (0.06, 3.98)

  1. BA bone age, BMI body mass index, CA chronologic age, GH growth hormone, IGF-1 insulin-like growth factor 1, SDS standard deviation score
  2. aAll values mean (SD) unless otherwise specified
  3. bPatient numbers reduced due to missing data