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Table 2 First-year response and responsiveness to GH treatment

From: Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria

  SGA GHD (all) Severe GHD (peak GH < 5 μg/L) Less-severe GHD (peak GH 5–10 μg/L)
n Mean SD Median p25 p75 n Mean SD Median p25 p75 n Mean SD Median p25 p75 n Mean SD Median p25 p75
Response parameters
 ∆ Height, SDSa 171 0.57 0.26 0.561 0.38 0.77 122 0.83 0.59 0.691 0.47 1.08 66 0.97 0.65 0.88 0.55 1.31 56 0.62 0.41 0.59 0.38 0.74
 HV, cm/year 171 8.1 1.5 8.21 7.2 9.2 122 9.4 2.6 9.01 7.6 10.9 66 10.1 2.8 9.9 8.4 12,0 56 8.4 1.9 8.3 7.2 9.5
 HV for age and sex, SDS 170 1.98 1.42 2.042 1.01 2.91 105 2.7 2.03 2.522 1.27 3.72 57 3.22 2.33 3.06 1.41 4.9 48 2.09 1.39 2.1 0.97 2.78
Parameters of estimated responsiveness
 HV Rankeb, SDS 171 −0.09 0.85 −0.08 −0.67 0.55 118 0,00 0.87 0.04 −0.57 0.53 63 0.03 0.92 −0.02 −0.47 0.64 55 −0.04 0.81 0.04 −0.58 0.37
 Studentized residual 159 −0.12 0.94 −0.02 −0.7 0.5 113 −0.35 1.13 0.263 −0.89 0.2 60 −0.43 1.3 −0.4 −0.93 0.3 53 −0.25 0.9 −0.16 −0.89 0.17
  1. SGA small for gestational age, GHD growth hormone deficiency, GH growth hormone, HV height velocity; again in height SDS after first-year GH treatment; bKIGS growth targets for first-year GH response; 1p < 0,001; 2p < 0,05; 3p < 0,05 vs. zero