Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria

Table 2 First-year response and responsiveness to GH treatment

	SGA						GHD (all)						Severe GHD (peak GH < 5 μg/L)						Less-severe GHD (peak GH 5–10 μg/L)
	n	Mean	SD	Median	p25	p75	n	Mean	SD	Median	p25	p75	n	Mean	SD	Median	p25	p75	n	Mean	SD	Median	p25	p75
Response parameters
∆ Height, SDS^a	171	0.57	0.26	0.56¹	0.38	0.77	122	0.83	0.59	0.69¹	0.47	1.08	66	0.97	0.65	0.88	0.55	1.31	56	0.62	0.41	0.59	0.38	0.74
HV, cm/year	171	8.1	1.5	8.2¹	7.2	9.2	122	9.4	2.6	9.0¹	7.6	10.9	66	10.1	2.8	9.9	8.4	12,0	56	8.4	1.9	8.3	7.2	9.5
HV for age and sex, SDS	170	1.98	1.42	2.04²	1.01	2.91	105	2.7	2.03	2.52²	1.27	3.72	57	3.22	2.33	3.06	1.41	4.9	48	2.09	1.39	2.1	0.97	2.78
Parameters of estimated responsiveness
HV Ranke^b, SDS	171	−0.09	0.85	−0.08	−0.67	0.55	118	0,00	0.87	0.04	−0.57	0.53	63	0.03	0.92	−0.02	−0.47	0.64	55	−0.04	0.81	0.04	−0.58	0.37
Studentized residual	159	−0.12	0.94	−0.02	−0.7	0.5	113	−0.35	1.13	0.26³	−0.89	0.2	60	−0.43	1.3	−0.4	−0.93	0.3	53	−0.25	0.9	−0.16	−0.89	0.17

SGA small for gestational age, GHD growth hormone deficiency, GH growth hormone, HV height velocity; ^again in height SDS after first-year GH treatment; ^bKIGS growth targets for first-year GH response; ¹p < 0,001; ²p < 0,05; ³p < 0,05 vs. zero

ISSN: 1687-9856