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Table 4 Multivariable models for delta cortisol

From: Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review

  Weight Height BSA (m2) Height z-score
  Coefficient p-value Coefficient p-value Coefficient p-value Coefficient p-value
Size factor −5.8 0.02* −128.3 0.003 ** −216.8 0.02 −71.5 0.02*
Indication for testing (vs GH sufficient short stature)
GHD   NS   NS   NS   NS
Concern for multi-pituitary abnormalities   NS   NS   NS   NS
Neoplasm with risk to pituitary   NS   NS   NS   NS
Exogenous glucocorticoid exposure −429 <0.0005** −256 <0.0005** −472 <0.0005**   NS
Known multi-pituitary abnormalities −230.0 0.05* −96 0.05*   NS   NS
Interaction variables (vs GH sufficient group*size factor)
GHD*(size factor)   NS     NS   NS
Concern for multi-pituitary*(size factor)   NS     NS   NS
Neoplasm*(size factor)   NS     NS   NS
Exogenous glucocorticoids*(size factor) 7.0 0.01*    245.5 0.03* 159 <0.0005**
Known multi-pituitary*(size factor)   NS     NS   NS
Baseline cortisol (nmol/L) −0.44 <0.0005** −0.46 <0.0005** −0.44 <0.0005** −0.40 <0.0005**
Delta ACTH (pmol/L) 2.47 <0.0005 2.49 <0.0005** 2.49 <0.0005** 2.22 <0.0005**
R2, n 0.3956, 222 0.3875, 22 0.3947, 222 0.4621, 222
  1. *p-value <0.05, **p-value < 0.005 by multivariate linear regression