Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review

Table 4 Multivariable models for delta cortisol

	Weight		Height		BSA (m²)		Height z-score
	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value
Size factor	−5.8	0.02*	−128.3	0.003 **	−216.8	0.02	−71.5	0.02*
Indication for testing (vs GH sufficient short stature)
GHD		NS		NS		NS		NS
Concern for multi-pituitary abnormalities		NS		NS		NS		NS
Neoplasm with risk to pituitary		NS		NS		NS		NS
Exogenous glucocorticoid exposure	−429	<0.0005**	−256	<0.0005**	−472	<0.0005**		NS
Known multi-pituitary abnormalities	−230.0	0.05*	−96	0.05*		NS		NS
Interaction variables (vs GH sufficient group*size factor)
GHD*(size factor)		NS				NS		NS
Concern for multi-pituitary*(size factor)		NS				NS		NS
Neoplasm*(size factor)		NS				NS		NS
Exogenous glucocorticoids*(size factor)	7.0	0.01*			245.5	0.03*	159	<0.0005**
Known multi-pituitary*(size factor)		NS				NS		NS
Baseline cortisol (nmol/L)	−0.44	<0.0005**	−0.46	<0.0005**	−0.44	<0.0005**	−0.40	<0.0005**
Delta ACTH (pmol/L)	2.47	<0.0005	2.49	<0.0005**	2.49	<0.0005**	2.22	<0.0005**
R², n	0.3956, 222		0.3875, 22		0.3947, 222		0.4621, 222

ISSN: 1687-9856