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Table 2 Median, range and 95 th centile for each urinary steroid metabolite ratio analysed for the whole group of controls as well as categorised by broad age groups

From: The pitfalls associated with urinary steroid metabolite ratios in children undergoing investigations for suspected disorders of steroid synthesis

   All controls N = 252 <6 months N = 12 6 months-10 yrs N = 106 >10 yrs N = 134
Enzyme defect Median age 10 years 2 months 5 years 13 years
(Range) (11d-18 yrs) (11 d-5 m) (6 m-9 yrs) (10–18 yrs)
M:F ratio 115:137 7:5 47:59 61:73
21-Hydroxylase def 17HP/(THE + THF + 5αTHF)     
Median (range) 0.01 (0–0.25) 0.01 (0.01-0.11) 0.01 (0–0.25) 0.01 (0–0.11)
95% centile 0.04 0.1 0.03 0.04
21-Hydroxylase def PT/(THE + THF + 5αTHF)     
Median (range) 0.03 (0–0.48) 0.02 (0.01-0.03) 0.02 (0–0.28) 0.06 (0.01-0.48)
95% centile 0.13 0.03 0.09 0.15
21-Hydroxylase def PTONE/(THE + THF + 5αTHF)     
Median (range) 0 (0–0.29) 0.01 (0–0.14) 0 (0–0.29) 0 (0–0.04)
95% centile 0.01 0.11 0.02 0.01
11β-Hydroxylase def THS/(THE + THF + 5αTHF)     
Median (range) 0.01 (0–0.09) 0 (0–0.04) 0.01 (0–0.09) 0 (0–0.02)
95% centile 0.02 0.03 0.03 0.01
3β-Hydroxysteroid dehydrogenase def DHEA/(THE + THF + 5αTHF)     
Median (range) 0 (0–1.25) 0.01 (0–0.1) 0 (0–1.25) 0 (0–0.31)
95% centile 0.12 0.1 0.03 0.14
P450 oxidoreductase def (17HP + PT)/(An + Et)     
Median (range) 0.38 (0.1-12.5) 1.95 (0.5-5) 0.75 (0.17-12.5) 0.23 (0.1-0.75)
95% centile 3.18 4.52 3.93 0.46
Apparent mineralocorticoid excess (THF + 5αTHF)/THE     
Median (range) 0.72 (0.01-7) 0.04 (0.01-0.35) 0.8 (0.15-7) 0.68 (0.25-.3.43)
95% centile 1.97 0.33 3.01 1.3
Apparent cortisone reductase deficiency THE/(THF + 5αTHF)     
Median (range) 1.4 (0.16-88.69) 22.82 (2.87-88.69) 1.25 (0.16-20.9) 1.49 (0.29-20.7)
95% centile 3.84 86.58 2.39 3
17β-Hydroxysteroid dehydrogenase deficiency (An + Et)/(THE + THF + 5αTHF)     
Median (range) 0.11 (0–1.65) 0.01 (0.01-0.09) 0.03 (0–0.75) 0.3 (0.04-1.65)
95% centile 0.7 0.07 0.23 0.9
5α-Reductase deficiency THF/5αTHF     
Median (range) 0.73 (0.08-25.25) 0.96 (0.19-5) 0.68 (0.08-25.25) 0.83 (0.22-2)
95% centile 1.75 4.19 1.93 1.71
5α-Reductase deficiency THB/5αTHB     
Median (range) 0.28 (0–68) 20.1 (0.33-68) 0.27 (0.02-47.64) 0.39 (0–2.05)
95% centile 3.89 53.06 1.97 1.24
5α-Reductase deficiency Et/An     
Median (range) 0.59 (0.03-4.86) 0.13 (0.03-1) 0.56 (0.06-4.86) 0.64 (0.26-2.1)
95% centile 1.7 0.69 2 1.5
  1. 17HP: 17-hydroxypregnanolone, PT: pregnanetriol, THE: tetrahydrocortisone, THF: tetrahydrocortisol. 5αTHF: 5α-tetrahydrocortisol. An: androsterone. Et: etiocholanolone. DHEA: dehydroepiandrosteroone. PTONE: pregnanetriolone. THS: tetrahydro-11-deoxycortisol. THB: tetrahydrocorticosterone. 5αTHB: 5α-tetrahydrocorticosterone.