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Table 1 Urinary steroid ratios and the number of cases with an abnormal ratio

From: The pitfalls associated with urinary steroid metabolite ratios in children undergoing investigations for suspected disorders of steroid synthesis

Ratio Cases analysed out of 93 Cases >95 th percentile Cases of suspected steroid disorder with ratio >95 th percentile (% of those with ratio >95 th percentile) Sensitivity Specificity Positive predictive value Negative predictive value
17HP/(THE + THF + 5αTHF) 93 (100%) 18 4 (22%) 100% 84% 22% 100%
PT/(THE + THF + 5αTHF) 92 (99%) 16 4 (25%) 100% 86% 25% 100%
PTONE/(THE + THF + 5αTHF) 61 (65%) 11 5 (45%) 100% 89% 45% 100%
THS/(THE + THF + 5αTHF) 92 (99%) 23 4(17%) 100% 78% 17% 100%
DHEA/(THE + THF + 5αTHF) 90 (96%) 12 2 (17%) 100% 90% 17% 100%
(17HP + PT)/(An + Et) 85 (90%) 6 2 (33%) 100% 95% 33% 100%
(THF + 5αTHF)/THE 93 (100%) 7 1 (14%) 100% 93% 14% 100%
THE/(THF + 5αTHF) 93 (100%) 9 1 (11%) 100% 91% 11% 100%
(An + Et)/(THE + THF + 5αTHF) 89 (95%) 6 1 (17%) 100% 94% 17% 100%
Et/An 84 (89%) 6 2 (33%) 100% 95% 33% 100%
THF/5αTHF 93 (100%) 10 2 (20%) 100% 91% 20% 100%
THB/5αTHB 86 (91%) 6 1 (17%) 100% 94% 17% 100%
  1. 17HP: 17-hydroxypregnanolone, PT: pregnanetriol, THE: tetrahydrocortisone, THF: tetrahydrocortisol. 5αTHF: 5a-tetrahydrocortisol. An:androsterone. Et: etiocholanolone. DHEA: dehydroepiandrosteroone. PTONE: pregnanetriolone. THS: tetrahydro-11-deoxycortisol. THS: tetrahydro-11-deoxycortisol. THB: tetrahydrocorticosterone. 5αTHB: 5α-tetrahydrocorticosterone.