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Mixed embryonal carcinoma – teratoma cause early puberty: a case report

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International Journal of Pediatric Endocrinology20152015 (Suppl 1) :P93

  • Published:


  • embryonal carcinoma
  • germ cell tumor


Mixed embryonal carcinoma – teratoma is defined a rare kind of germ cell tumor, especially in children. Objective: a rare case report with early puberty due to mixed embryonal carcinoma – teratoma.


A 3 year 7 month old boy presented with early puberty and adrenal tumor in National Hospital of Pediatrics.


A case report.


A 3 year 7 month old boy presented with enlargement of penis, acnes, pubic hair, deep voice. He admitted with his height of +2.3SDS, penis length of 6cm, testes volumn of 4ml, pubic hair P2 (tanner). Abdoment ultrasound and CT scan showed adrenal tumor. Serum laboratory showed: 17 OHP 3,8 ng/ml, testosteron 32,3 nmol/l, cortisol 8h 433,9 nmol/l, cortisol 22h 39,2 nmol/l, glucose 3,7 mmol/l, αFP 3945,9 u/l, electrolyte normal; urine VMA 15,5 µmol/24h; bone age 5 years. Surgical showed the tumor did not originate from the adrenal. Histologica showed mixed embryonal carcinoma – teratoma. After surgeon, the signs of virilization reduce, serum testosteron become normal.


Mixed embryonal carcinoma – teratoma can be caused testosterone excretion and early puberty.

Written informed consent was obtained from the patient's parent or guardian for publication of this Case report (and any accompanying images). A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Authors’ Affiliations

Department of Endocrinology, Metabolism and Genetics, National Hospital of Pediatrics, Hanoi, Vietnam
Surgical department, National Hospital of Pediatrics, Hanoi, Vietnam
Anatomical department, National Hospital of Pediatrics, Hanoi, Vietnam


© Ngoc et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.