Volume 2015 Supplement 1

Abstracts from the 8th APPES Biennial Scientific Meeting

Open Access

Response to vitamin d replacement in overweight and normal weight children with vitamin D deficiency

  • Haejung Kim1,
  • In Hyuk Chung2 and
  • Eun-Gyong Yoo1
International Journal of Pediatric Endocrinology20152015(Suppl 1):P76

https://doi.org/10.1186/1687-9856-2015-S1-P76

Published: 28 April 2015

Aims

Obesity is a risk factor for vitamin D deficiency (VDD), because the lipid soluble vitamin D can be sequestered in adipose tissue. Although it was suggested that higher dose of vitamin D might be required to treat VDD in obese individuals, little is known about treatment responses in overweight children. We investigated the response to vitamin D replacement in normal weight and overweight children.

Methods

This is a prospective study including 66 Korean children between 8 and15 years of age diagnosed with VDD between Dec 2013 and Feb 2014. VDD was defined as serum 25OHD < 20 ng/mL, and vitamin D sufficiency as ≥30 ng/mL. Overweight was defined as body mass index (BMI) ≥85th percentile (n = 25), and normal weight as BMI between 5th and 84th percentile (n = 41). All participants received vitamin D3 supplementation (2000 IU/d) for 8 weeks. The level of serum 25OHD, PTH, and biochemical parameters were measured before and after treatment.

Results

The mean age was 9.9 ± 1.4 years in normal weight children and 10.0 ± 2.1 years in overweight children (p=ns). Baseline serum 25OHD level was lower in normal weight children (13.2 ± 3.2 ng/mL) than in overweight children (14.2 ± 2.1 ng/mL, p=0.011). Baseline PTH level was 32.3 ± 9.5 and 39.5 ± 18.0 pg/mL in normal weight and overweight children, respectively (p=0.027). After 8 weeks of treatment, 28 (68.3%) normal weight children and 10 (40%) overweight children achieved vitamin D sufficiency (p=0.023). The mean serum 25OHD level was 33.7 and 28.6 ng/mL in normal weight and overweight children, respectively (p=0.496). The increase of 25OHD levels after treatment was significantly higher in normal weight children than in overweight children (20.6 ± 7.2 vs. 14.4 ± 7.9 ng/mL, p=0.002). However, the decrease in PTH levels seemed to be slightly larger in overweight children compared to normal weight children (-3.2 ± 20.8 vs. -1.1 ± 11.1 pg/mL, p=0.05). In multiple regression analysis, overweight was significantly related to the 25OHD increase after vitamin D replacement (β=0.323, p=0.01).

Conclusion

The response to vitamin D replacement can be influenced by adiposity, and overweight children require larger doses of vitamin D to achieve vitamin D sufficiency.

Authors’ Affiliations

(1)
Department of Pediatrics, CHA University
(2)
Department of Pediatrics, National Health Corporation, Ilsan Hospital

Copyright

© Kim et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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