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  • Open Access

Correlation between C-reactive protein levels and affecting factors for adiposity in apparently healthy Korean adolescents

  • 1,
  • 2,
  • 2 and
  • 3
International Journal of Pediatric Endocrinology20152015 (Suppl 1) :P69

  • Published:


  • Diastolic Blood Pressure
  • Waist Circumference
  • Middle School Student
  • Multivariate Linear Regression Analysis
  • Healthy Adolescent


Recent studies have shown that C-reactive protein is not just an indicator of cardiovascular disease (CVD) incidence and mortality. Thus, early detection of a continous increase in CRP concentrations may be useful in predicting subsequent development of CVD or metabolic syndrome.

The objective of this study was to analyze high sensitivity C-reactive protein (hs-CRP) in apparently healthy young Korean adolescents and determine confounding factors for high hs-CRP in this population.


We enrolled 197 middle school students (93 boys and 104 girls) who participated in a general health check-up at a tertiary hospital in Seoul. We measured height, weight, waist circumference and blood pressure and investigated hs-CRP concentrations, insulin levels, insulin resistance and lipid profiles. Hs-CRP levels were measured using the Behring BN II nephelometer (Dade Boering, Marburg, Germany) and log-transformed for analysis.


hs-CRP concentration was significantly higher in boys than in girls (P=0.012). Pearson’s correlation coefficients revealed a significant correlation between log- transformed hs-CRP and BMI (r=0.24, P=0.0008), waist circumference (r=0.24, P=0.0007), systolic (r=0.17, P=0.019) and diastolic blood pressure (r=0.23, P=0.014), and ALT (r=0.16, P=0.023). In stepwise multivariate linear regression analysis, sex (male gender), waist circumference, and diastolic blood pressure were positively and fasting serum HDL-cholesterol level was negatively associated with log-transformed hs-CRP.


We found that there exists a gender difference in hs-CRP concentrations in apparently healthy adolescents and that log-transformed hs-CRP concentrations were positively associated with male, waist circumference and diastolic blood pressure and negatively associated with HDL-cholesterol level. The gender difference and the contibuting factors for hs-CRP found in these healthy adolescents suggests a possibly relevant pathophysiological mechanism involved in the increase of cardiovascular risk associated with childhood obesity.

Authors’ Affiliations

Department of Pediatris, CHA Gangnam Medical center, CHA University, Seoul, Korea
Department of Family Medicine, Yongin Severance hospital, Yensei University, Geonggi, Korea
Department of Pediatrics, National Medical Center, Seoul, Korea


© Kim et al; licensee BioMed Central Ltd. 2015

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