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Effect of bisphosphonate treatment in osteogenesis imperfecta children in Cipto Mangunkusumo Hospital Jakarta


Bisphosphonates are the mainstay of pharmacologic fracture-prevention therapy for most forms of osteogenesis imperfecta (OI). Studies suggests that bisphosphonate treatment may significantly improve the natural history of all type of OI, particularly by decreasing the rate of fracture, increasing bone mineral density, decreasing bone pain, and significantly increasing height.


To evaluate the effect of bisphosphonate treatment in OI children treated in Cipto Mangunkusumo Hospital (CMH) Jakarta.


We retrospectively studied the data of age, gender, age at diagnosis, bisphosphonate treatment, and its effects in OI patients in CMH from Indonesian OI children registry, which is documented from January 2012 to May 2014.


Seventy-seven OI cases (39 male), which were diagnosed at the age of 1 - 9 years old were recorded. Five patients underwent surgery and three patients died before commencing treatment. Nine patients received intravenous pamidronate and sixteen patients received zolendronic acid therapy. Liver and renal functions, as well as serum electrolyte levels were evaluated before and after treatment. Eight patients reported hyperthermia and three others experienced fatigue, bone pain, and abdominal pain within 24 hours of therapy. Serum calcium level decreased in eight patients. No serious adverse effects were documented.


All registered OI cases patients that received bisphosphonates treatment showed no serious adverse effects.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Pulungan, A., Batubara, J., Tridjaja, B. et al. Effect of bisphosphonate treatment in osteogenesis imperfecta children in Cipto Mangunkusumo Hospital Jakarta. Int J Pediatr Endocrinol 2015 (Suppl 1), P61 (2015).

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