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Disease-specific growth charts of Marfan syndrome in Korea


Understanding the growth pattern in Marfan syndrome (MFS) is useful for predicting adult height and for planning the timing of growth reduction therapy. We have reviewed the growth parameters of patients with MFS in Korea and generated the Korean MFS-specific growth curve for understanding the growth pattern in MFS.


Anthropometric data were available from 187 males and 152 females with MFS through a retrospective review of medical records. The standardized growth curves were constructed for weight and height according to gender. Comparisons between MFS patients and the general population were performed using a one-sample T-test.


Korean MFS patients had similar height and weight compared with the general population at birth. However, linear growth curve of Korean MFS after two years of age showed that the 50th percentile of MFS is above the 97th percentile of normal in both genders. Regarding body mass, although the mean body weight of MFS patients was larger than that of the general population in males and females, the gap of the mean weight curve was small. In the Korean MFS growth curve, the growth pattern and final adult height were nearly analogous to those of the United States (US).


Korean MFS-specific growth charts showed that an excessive growth pattern began in the early infant period, which was prominent in terms of linear growth compared to body mass. There were no ethnic differences in the growth pattern compared with Western MFS patients.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Kim, S.J., Park, S.W., Kwun, Y. et al. Disease-specific growth charts of Marfan syndrome in Korea. Int J Pediatr Endocrinol 2015 (Suppl 1), P30 (2015).

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  • Growth Curve
  • Growth Pattern
  • Linear Growth
  • Early Infant
  • Anthropometric Data