Skip to content


International Journal of Pediatric Endocrinology

Open Access

The relationship of serum 25-hydroxyvitamin D with glucose homeostasis in obese children and adolescents in Zhejiang, China

  • Ke Huang1,
  • You-Jun Jiang1,
  • Jun-Fen Fu1,
  • Jian-Feng Liang2,
  • Hong Zhu3,
  • Li-Fei Hu3,
  • Zhi-Wei Zhu3,
  • Guan-Pin Dong1 and
  • Xue-Feng Chen1
International Journal of Pediatric Endocrinology20152015(Suppl 1):O49

Published: 28 April 2015


Insulin SensitivityGlucose MetabolismOral Glucose Tolerance TestObese ChildImpaired Fasting Glucose


Evidence of the association between vitamin D, insulin resistance and oral disposition index (oDI) in obese children and adolescents is limited. We investigated serum 25(OH) D levels in obese children and adolescents in Zhejiang, China, and determined the relationship between serum 25(OH) D and glucose metabolism.


A cross-sectional design was used. All together 348 obese and 445 non-obese children and adolescents (aged from 6-16 years old) were enrolled in this study. Obese children were divided into four subgroups: normal glucose tolerance (NGT), isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG and ITG (IFG+ITG) according to the oral glucose tolerance test. We measured serum 25(OH) D levels and calculated the homeostasis model of insulin resistance (HOMA-IR), the whole body insulin sensitivity index (WBISI), the product of β-cell function and insulin sensitivity by the disposition index (DI).


The levels of 25(OH)D in obese group were significantly lower than those of non-obese group; serum 25(OH)D level in obese with NGT group was higher than that of the other three subgroups, and it was significantly inversed with LogHOMA-IR (r=-0.114, p=0.035), positively correlated with LogWBISI, LogHOMA0DI after control for age, sex, season, puberty stage (r=0.111, p=0.040; r=0.122, p=0.024). Obese patients with vitamin D deficiency have a significantly higher risk of disturbing the glucose metabolism, such as IFG, ITG, IFG plus ITG, either IFG or ITG, for its OR 3.198(95%CI 1.467-6.97), 5.443(95%CI 1.863-15.897), 5.560(95%CI 1.212-25.502), 4.007(95%CI 2.017-7.962).


25(OH) D deficiencies or insufficiency are common in obese children and adolescents in Zhejiang, China. Obese patients with 25(OH) D deficiency (<30nmol /L) are at higher risk for abnormal glucose metabolism.

Authors’ Affiliations

Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
Department of Statistics, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
Department of Child Health Care, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China


© Huang et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.