Skip to main content

Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year old

Aims

To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-month to 2-year old.

Methods

We set a case-control study, a total of 251 female infants (aged 4 months to 2 years) with premature thelarche and 33 healthy age-matched control subjects were enrolled. Test the serum bisphenol A (serum BPA) concentration by liquid-liquid extraction coupled with ultra-performance liquid chromatography tandem mass spectrometry.

Results

The mean serum BPA levels in the normal and premature thelarche groups were 1.70 ng/ml and 3.48 ng/ml respectively. Serum BPA concentration in the premature thelarche group was significantly greater than that in the control group. There was no correlation between age and serum BPA level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA falls down as the age growing.

Conclusions

This hospital-based study implies that the association between serum BPA concentrations and premature thelarche. Additionally, the serum BPA levels are much higher than we ever thought in infants, and much more concerns should be raised in infants aged 4-month to 2-year old.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Lian-hui Chen.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chen, L., Shi, J., Fang, Y. et al. Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year old. Int J Pediatr Endocrinol 2015, O45 (2015). https://doi.org/10.1186/1687-9856-2015-S1-O45

Download citation

Keywords

  • Tandem Mass Spectrometry
  • Chromatography Tandem Mass
  • Chromatography Tandem Mass Spectrometry
  • Liquid Chromatography Tandem Mass Spectrometry
  • Liquid Chromatography Tandem Mass