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Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year old
International Journal of Pediatric Endocrinology volume 2015, Article number: O45 (2015)
To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-month to 2-year old.
We set a case-control study, a total of 251 female infants (aged 4 months to 2 years) with premature thelarche and 33 healthy age-matched control subjects were enrolled. Test the serum bisphenol A (serum BPA) concentration by liquid-liquid extraction coupled with ultra-performance liquid chromatography tandem mass spectrometry.
The mean serum BPA levels in the normal and premature thelarche groups were 1.70 ng/ml and 3.48 ng/ml respectively. Serum BPA concentration in the premature thelarche group was significantly greater than that in the control group. There was no correlation between age and serum BPA level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA falls down as the age growing.
This hospital-based study implies that the association between serum BPA concentrations and premature thelarche. Additionally, the serum BPA levels are much higher than we ever thought in infants, and much more concerns should be raised in infants aged 4-month to 2-year old.
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Chen, L., Shi, J., Fang, Y. et al. Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year old. Int J Pediatr Endocrinol 2015, O45 (2015). https://doi.org/10.1186/1687-9856-2015-S1-O45
- Tandem Mass Spectrometry
- Chromatography Tandem Mass
- Chromatography Tandem Mass Spectrometry
- Liquid Chromatography Tandem Mass Spectrometry
- Liquid Chromatography Tandem Mass