Skip to content


  • Oral presentation
  • Open Access

Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year old

  • 1,
  • 2,
  • 1,
  • 1,
  • 3 and
  • 3
International Journal of Pediatric Endocrinology20152015 (Suppl 1) :O45

  • Published:


  • Tandem Mass Spectrometry
  • Chromatography Tandem Mass
  • Chromatography Tandem Mass Spectrometry
  • Liquid Chromatography Tandem Mass Spectrometry
  • Liquid Chromatography Tandem Mass


To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-month to 2-year old.


We set a case-control study, a total of 251 female infants (aged 4 months to 2 years) with premature thelarche and 33 healthy age-matched control subjects were enrolled. Test the serum bisphenol A (serum BPA) concentration by liquid-liquid extraction coupled with ultra-performance liquid chromatography tandem mass spectrometry.


The mean serum BPA levels in the normal and premature thelarche groups were 1.70 ng/ml and 3.48 ng/ml respectively. Serum BPA concentration in the premature thelarche group was significantly greater than that in the control group. There was no correlation between age and serum BPA level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA falls down as the age growing.


This hospital-based study implies that the association between serum BPA concentrations and premature thelarche. Additionally, the serum BPA levels are much higher than we ever thought in infants, and much more concerns should be raised in infants aged 4-month to 2-year old.

Authors’ Affiliations

Department of Pediatrics, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Zhejiang Quality Inspection Institute of Science, Hangzhou, Zhejiang, China


© Chen et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.