Skip to main content

Advertisement

Resistance training improves metainflammation and body composition in obese adolescents

Adolescent obesity is associated with inflammation, insulin resistance and prediabetes. The purpose of the study was to investigate whether resistance training (RT) improves the adipokine profile, body composition and insulin sensitivity of obese adolescents. Fourteen obese adolescents (16.1+1.6 y; M:F 6:8; body mass index (BMI) SDS 2.01 + 0.31) were recruited for a 16-week RT intervention. Thirty-one lean youth (15.6+1.3 y; M:F 19:12; BMI SDS -0.03+0.07) had baseline anthropometric measurements and blood tests for comparison. Participants completed 3 RT sessions per week with training load progressively increased from 60% to 85% of one repetition maximum (1-RM). The following parameters were examined pre- and post-intervention: 1) Height, weight, BMI; 2) High sensitivity C-reactive protein (hs-CRP) and adipokines including interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha (TNF-α), adiponectin, soluble intercellular adhesion molecule (sICAM)-1, leptin and resistin; 3) Body composition by dual energy x-ray absorptiometry (DXA), and 4) Insulin sensitivity by homeostatic model assessment (HOMA-IR). Obese youth had significantly higher IL-1β, leptin and resistin (all p<0.0001) and lower adiponectin and sICAM-1 (both p<0.0001) at baseline compared with lean youth. Post-intervention, a reduction in IL-6 (p<0.01), IL-1β (p<0.01) and resistin (p <0.001) was observed whereas adiponectin and sICAM-1 increased (p<0.05, p<0.001 respectively) in obese adolescents. HOMA and hs-CRP remained unchanged. IL-1 β and sICAM-1 levels in obese youth normalised to levels comparable to lean youth post-intervention (p = 0.1 and p=0.2), whereas TNF-α and resistin were significantly lower (p<0.05, p<0.01 respectively) post-intervention in the obese youth. Percent fat for the trunk, arm and total body (p<0.05) were reduced, while fat free mass (p<0.01) was increased after the intervention. RT is a feasible intervention to improve the adipokine profile and body composition of obese adolescents suggesting it may be a feasible intervention for improving metabolic health in obese youth at high risk of Type 2 Diabetes.

Author information

Correspondence to Rachana Dahiya.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Dahiya, R., Shultz, S., Cardinal, J. et al. Resistance training improves metainflammation and body composition in obese adolescents. Int J Pediatr Endocrinol 2015, O40 (2015). https://doi.org/10.1186/1687-9856-2015-S1-O40

Download citation

Keywords

  • Body Composition
  • Resistance Training
  • Obese Adolescent
  • Feasible Intervention
  • Homeostatic Model Assessment