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Table 1 Characteristics of the 24 adolescent males at onset of rhGH or rhGH + Anastrazole administration and historical controls

From: A randomized pilot trial of growth hormone with anastrozole versus growth hormone alone, starting at the very end of puberty in adolescents with idiopathic short stature

  GH alone GH + Anastrazole Historicals controls
N 12 12 17
Father’s height    
 cm 168.5 ± 4.9 168.9 ± 3.6 169.2 ± 4.1
 SDS - 1.2 ± 0.8 - 1.1 ± 0.6 −1.1 ± 0.8
Mother’s height    
 cm 157.8 ± 5.8 156.4 ± 6 157.9 ± 5
 SDS - 1.2 ± 1 - 1.2 ± 1.1 −1.2 ± 1
Birth length (cm) 48.3 ± 1 48.2 ± 1.2 48.4 ± 1.2
Age (yrs) 15.2 ± 1.1 15.2 ± 0.8 15.1 ± 0.8
Height    
 cm 156.3 ± 2.9 155.9 ± 4 156.1 ± 3.5
 SDS - 1.70 ± 1 - 1.70 ± 0.7 −1.67 ± 0.8
Weight (kg) 49.8 ± 4 48 ± 6 49.9 ± 4
Testes volume (ml) 22.4 ± 8 22.2 ± 5 22 ± 5
Serum testosterone (ng/ml) 5.5 ± 0.9 5.6 ± 0.9 5.5 ± 0.8
Bone age at hand (yrs) 14.6 ± 0.6 14.5 ± 0.8 14.6 ± 0.7
Knee score* 2.8 ± 0.7 2.8 ± 0.4 2.7 ± 0.4 (N = 10)
IGF1 (SDS) - 0.5 ± 0.4 - 0.3 ± 0.6 −0.4 ± 0.6 (N = 10)
  1. We observed no significant differences between the groups. Values are expressed as mean ± SD.
  2. *see Methods.