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Table 6 Analysis of Intent to Treat to Adult Height Treatment Response with rhGH

From: Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

  Number Years observation (Mean SDS ± SD) Growth rate cm/yr (Mean SDS ± SD) Δ Height SDS (Mean SDS ± SD)
Males pretreatment     
 Lost to follow-up 22 2.46 ± 1.87 4.29 ± 1.42 -0.31 ± 0.48
 Treated to AH 50 2.42 ± 1.37 4.00 ± 1.02 -0.33 ± 0.54
    p, 0.426 p, 0.902
On treatment with rhGH
Before puberty     
 Lost to follow - up 21 1.20 ± 1.02 7.92 ± 0.94 0.53 ± 0.41
 Treated to AH 41 1.83 ± 1.51 8.31 ± 1.44 0.71 ± 0.57
    p, 0.207 p, 0.179
During puberty     
 Lost to follow - up 7 1.34 ± 0.75 9.09 ± 2.24 0.50 ± 0.28
 Treated to AH 50 2.05 ± 1.04 8.31 ± 1.74 0.72 ± 0.48
    p, 0.404 p, 0.116
Females pretreatment
 Lost to follow-up 5 2.76 ± 1.54 3.78 ± 1.40 -0.56 ± 0.49
 Treated to AH 17 3.71 ± 2.34 4.56 ± 0.71 -0.50 ± 0.37
    p, 0.293 p, 0.810
On treatment with rhGH
Before puberty     
 Lost to follow - up 5 1.01 ± 0.25 8.06 ± 1.36 0.48 ± 0.32
 Treated to AH 10 1.20 ± 0.51 8.94 ± 0.92 0.58 ± 0.27
    p, 0.241 p, 0.593
During puberty     
 Lost to follow - up 2 1.02 ± 0.03 9.34 ± 2.07 0.72 ± 0.58
 Treated to AH 20 1.94 ± 0.97 7.30 ± 1.77 1.05 ± 0.45
    p, 0.382 p, 0.559