Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

Table 11 NFSS & FSS Adult Height Gain of Controls and Treated Subjects SDS (95% CI)

		GH Dosage	Adult height gain of controls untreated	NFSS to FSS Difference	Adult height gain of treated subjects	NFSS to FSS Difference
Published study	No.	mg/kg/wk	Mean SDS (95% CI)	SDS p	Mean SDS (95% CI)	SDS p
Wit et al. NFSS [9]	36	0.32 to 0.14	0.8 (0.62 to 0.98)	0.5 SDS p <0.01	1.50 (1.23 to 1.77)	0.7 SDS p <0.05
Wit et al. [9] FSS	5	0.32 to 0.27	0.3 (-0.05 to 0.65)	0.5 SDS p <0.01	0.80 (0.06 to 1.54)	0.7 SDS p <0.05
Albertsson-Wikland et al. NFSS [3]	48	0.47	0.5 (0.23 to 0.77)	0.6 SDS p <0.05	1.40 (1.17 to 1.63)	0.5 SDS p < 0.05
Albertsson-Wikland et al. [3] FSS	14	0.47	-0.1 (-0.79 to 0.59)	0.6 SDS p <0.05	0.90 (0.44 to 1.36)	0.5 SDS p < 0.05
			*Adult height*		*Adult height gain*
Our Study NFSS (treated)	63	0.32 (0.03)	-0.56 (-0.72 to -0.40)	0.52 SDS p < 0.01	2.06 (1.87 to 2.25)	0.55 SDS p <0.001
Our Study FSS (treated)	25	0.32 (0.03)	-1.08 (-1.41 to -0.75)	0.52 SDS p < 0.01	1.51 (1.24 to 1.78)	0.55 SDS p <0.001

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