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  • Poster presentation
  • Open Access

Correlation of leptin, neuropeptide Y and amylin in childhood obesity

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  • 2,
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  • 3
International Journal of Pediatric Endocrinology20132013 (Suppl 1) :P97

  • Published:


  • Leptin
  • Neuropeptide Y
  • Amylin
  • Childhood obesity


To investigate the correlation of the serum leptin, NPY, amylin in the childhood obesity.


The body mass index (BMI), waist and hip circumference, blood pressure (systolic/diastolic), lipid profile, fasting glucose, insulin, leptin, neuropeptide Y(NPY), amylin were measured in 56 children (24 obese children and 32 non-obese controls). We calculated HOMA-IR and evaluated the relationship between each anthropometric data, metabolic bio-marker and diet regulating factor (leptin, NPY, amylin).


Insulin and total cholesterol, triglyceride, LDL-cholesterol levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin, NPY, leptin/NPY ratio, amylin levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin showed significant correlation with BMI (r= 0.379, p= 0.043), NPY (r= 0.377, p= 0.044), L/N ratio (r= 0.754, p= 0.000) in the obese group. amylin showed significant correlation with insulin (r= 0.400, p= 0.048), HOMA-IR (r= 0.459, p= 0.028) in the obese group.


There is abnormality in central diet regulatory system caused by leptin and neuropeptide Y resistance in the obese group. And amylin showed significant correlation with insulin resistance

Authors’ Affiliations

Department of Pediatrics, Chosun University School of Medicine, Gwangju, Korea
Department of Pediatrics, Daejin Medical Center, Seongnam, Korea
Department of Pediatrics, Wonkwang University Sabon Medical Center, Gunpo, Korea


© Kim et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.