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  • Open Access

The effect of vitamin c supplementation on intercellular adhesion molecule-1 (ICAM-1) concentration on male adolescent obesity in Padang

  • 1,
  • 1 and
  • 1
International Journal of Pediatric Endocrinology20132013 (Suppl 1) :P86

https://doi.org/10.1186/1687-9856-2013-S1-P86

  • Published:

Keywords

  • Adolescent
  • Obesity
  • Vitamin C
  • ICAM-1

Background

The role of Vitamin C as antioxidant has been known. Obesity is an oxidative stress condition which becomes risk factor of cardiovascular disease, which could be detected through ICAM-1 concentration.

Objective

To examine the effect of Vitamin C supplementation on the ICAM-1 concentration on male adolescent obesity in Padang.

Method

The randomized double blind controlled trial of 40 obese adolescent boys aged 14-18 years old were performed on March-May 2011. Subjects were classified into 2 groups, the Vitamin C 500 mg treatment group and the control group which got placebo, twice daily for 8 weeks. The ICAM-1 concentration of both groups was examined before and after the treatment. The data were analyzed with paired sample t-test and independant t-test with significant degree p<0.05.

Result

The mean of initial ICAM-1 concentration in Vitamin C and placebo group were 370.37 (SD155.09) ng/ml and 232.96 (SD 106.48) ng/ml, respectively. After 8 weeks treatment, the mean of ICAM-1 concentration on the vitamin C and placebo group were 183.32 (SD 52.34) ng/ml and 185.06 (SD 52.34) ng/ml; the mean of ICAM-1 concentration decreased in both group with p 0.007 and <0.05, concecutively. The reducing Delta of ICAM-1 concentration in vitamin C and placebo group were 187.04 (SD 131.5) ng/ml and 47.91 (SD 62.25) ng/ml, respectively. The reducing Delta of ICAM-1 concentration in Vitamin C group were higher than placebo group, with ratio 3.9 : 1 (p<0.05).

Conclusion

Vitamin C supplementation in obese adolescent boys reduce the ICAM-1 concentration.

Authors’ Affiliations

(1)
Endocrinology Division, Pediatric Health Departement of Medical Faculty Andalas University, Dr. M. Djamil Hospital, Padang

Copyright

© Hernofialdi et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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