Volume 2013 Supplement 1

7th Asia Pacific Paediatric Endocrine Society (APPES) Biennial Scientific Meeting

Open Access

Clinical and laboratory characteristics of Prader-Willi syndrome

  • Bui Phuong Thao1,
  • Vu Chi Dung1,
  • Nguyen Ngoc Khanh1,
  • Can Thi Bich Ngoc1,
  • Ngo Diem Ngoc1,
  • Dinh Thi Hong Nhung1,
  • An Thuy Lan1,
  • Nguyen Thi Mai2,
  • Nguyen Phu Dat2 and
  • Nguyen Thi Hoan1
International Journal of Pediatric Endocrinology20132013(Suppl 1):P60

https://doi.org/10.1186/1687-9856-2013-S1-P60

Published: 3 October 2013

Prader-Willi syndrome (PWS) is a complex multisystem genetic disorder due the lack of expression of paternally inherited imprinted genes on chromosome 15q11-13. Clinical presentation includes hypotonia, hyperphagia, obesity, hypogonadism, learning difficulty. We studied clinical and laboratory of patient diagnosed and treated in National Hospital of Pediatrics, Hanoi (NHP). This is descriptive study. We collected 26 patients diagnosed of PWS by FISH in NHP from December 2007 to April 2012 were recruited in the study. Male/female ratio was 6/1. Patients diagnosed before 5 years occupied 53.5%. 85.7% of patients were found to have hypotonia at age of 4.92.0 months. 86.4% of patients had hypherphagia at age of 20.711.1 months. In patients aged of > 2 years, height SDS was +8.74.7 SD compared to gender and age. The figure of BMI was +10.33 SD. 4/7 of patients aged ≥ 6 years had micropenis. 91.7% of patients had cryptorchidism. 4/24 of patients (14.3%) had type 2 diabetes mellitus. Based on clinical presentation, more PWS patients could be diagnosed and treated early.

Authors’ Affiliations

(1)
National Hospital of Pediatrics
(2)
Hanoi Medical University

Copyright

© Thao et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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