Skip to main content
  • Poster presentation
  • Open access
  • Published:

Multiple pituitary hormone deficiency: beware of combined hormones deficiency

Multiple Pituitary Hormone Deficiency (MPHD) is an endocrine disorder due to combination of pituitary hormones deficiencies. Clinical manifestations vary due to the combination of individual hormone deficiencies. The diagnosis is established based on history, signs and symptoms, hormonal and radiological examination. MPHD should be managed by hormones replacement according hormone abnormalities. The objective is to present a case of multiple pituitary hormones deficiency in a child, focusing in diagnosis and management.

A 14 years-old boy, come with main complaint of short stature and delayed puberty. The height was below the 3rd percentile for age. Patient also suffered from micropenis. Tanner stage was prepuberta. Laboratories showed peak stimulated growth hormone concentration test was below 10 ng/mL, low levels of IGF 1 and IGF-BP3; FT4: 5.99ng/dl (normal:4.6-11),TSH: 3.08 IU/mL (normal:0.4-7.0); non stimulated LH level: 0.23 mIU/µL (cut-off limit prepubertal-pubertal level was 0.6 IU/L), FSH: 1.6 mIU/µL; testosrone: <15 ng/dL (normal basal testosterone: 19 ng/L). Working diagnosis was GH deficiency and hypogonadotrophic hypogonadism. This patient treated with growth hormone and testosterone. The height increased 10 cm during 10 months growth hormone treatment and the penile length increased became normal range. This paper reported growth hormone deficiencies accompanied by hypogonadotrophic hypogonadism. Facing patient with pituitary hormone deficiency must be aware of the abnormality of other pituitary hormone.

Author information

Authors and Affiliations

Authors

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Rochmah, N., Faizi, M., Yuniari, A. et al. Multiple pituitary hormone deficiency: beware of combined hormones deficiency. Int J Pediatr Endocrinol 2013 (Suppl 1), P198 (2013). https://doi.org/10.1186/1687-9856-2013-S1-P198

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/1687-9856-2013-S1-P198

Keywords