Volume 2013 Supplement 1

7th Asia Pacific Paediatric Endocrine Society (APPES) Biennial Scientific Meeting

Open Access

Congenital adrenal hyperplasia- presenting as central precocious puberty

  • Vimal Mavila Veetil1 and
  • MC Naseerali1
International Journal of Pediatric Endocrinology20132013(Suppl 1):P118

https://doi.org/10.1186/1687-9856-2013-S1-P118

Published: 3 October 2013

Aims

To demonstrate the presentation of Congenital adrenal hyperplasia (CAH) as central precocious puberty.

Materials and methods

4 children with mean age of 6.5 (5.5, 6.5, 6.5, 7.5) who presented to the out patient department with precocious puberty between December 2008 to December 2011were studied.

Results

3 were boys, out of which 2 were twins. 3 boys were diagnosed to have CAH after presentation to the OPD. They had mean bone age of 12 years. They had elevated testosterone (mean : 2.4 ng/ml) and 17 hydoxyprogesterone ( mean : 24 ng/ml ) at presentation. They had clinical (testicular volume 5ml) and biochemical (mean basal LH : 6 ng/ml )evidence of central precocious puberty. The girl was already diagnosed to have CAH at birth itself, but was on irregular treatment. She presented with menarche at the age of 7.5 and had basal LH of 8 ng/ml. All the patients were started on replacement with hydrocortisone, fludrocortisones and GnRH analogue ( Leuprolide depot ).

Conclusions

Central precocity may be due to undiagnosed CAH . Improperly treated CAH may also lead to central precocious puberty. Treatment may involve GnRH analogues along with adrenal steroids.

Authors’ Affiliations

(1)
MIMS

Copyright

© Veetil and Naseerali; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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