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Adrenal cortex tumors: clinical features and laboratory finding

The adrenal cortex tumors (ACT) include both malignant adrenal cortex cancers and benign masses that can be either secreting, of one of the hormones normally produced in the adrenal cortex or non-secretory. We describe clinical features and laboratory finding of patients with adrenal cortex tumors. This is a case series report. 29 cases of childhood with adrenal cortex tumors treated at the Vietnam National Hospital of Pediatrics in a period of 1995–2011 have been reviewed in detail the presenting features and laboratory. The study recruited 15 boys and 14 girls. The median age at diagnosis was 4.97 ± 3.61 yrs (range, 20 days to 14 yrs); 19 patients were younger than 5 yrs. Hypertension and cushingoid features were common in patients (62%, 58.6%), virilization was presenting feature in 44.8% of the group. An abdominal mass was palpable in 20.7 % of the patients. High level of testosterone was common in patients (94.1%). 30% of the patients had hypercotisonemia. All tumors were unilateral; the right adrenal glands predominated over left (1.9 :1). 62.5 % tumors over 4 cm. 22 patients had received operation to remove the tumors: 11 carcinoma, 2 adenocarcinoma. In conclusion, high percentage of patients had malignant tumors among ACT operated patients.

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Correspondence to Can Thi Bich Ngoc.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ngoc, C.T.B., Dung, V.C., Thao, B.P. et al. Adrenal cortex tumors: clinical features and laboratory finding. Int J Pediatr Endocrinol 2013, P110 (2013).

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  • Carcinoma
  • Hypertension
  • Internal Medicine
  • Adenocarcinoma
  • Testosterone