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International Journal of Pediatric Endocrinology

Open Access

The effect of eggplant (Solanum melongena L.) extract peroal against blood glucose level of white rat (Ratus novergicus) wistar strain diabetic model

  • Nanda Rela Qonita1,
  • Maimun Zulhaidah1,
  • Sudiarto1 and
  • Harjoedi Adji Tjahjono1
International Journal of Pediatric Endocrinology20132013(Suppl 1):O33

https://doi.org/10.1186/1687-9856-2013-S1-O33

Published: 3 October 2013

Eggpant (Solanum melongena L.) that are common in Indonesia are already known contain anthocyanins as antioxidants as well as α-glukosidase inhibitor that can inhibit the rise of blood glucose in diabetes mellitus (DM). This study aimed to determine that the eggplant extract has antihyperglicemic effect and the effective dose as well. This was an experimental study with post test only control group design. We used 25 rats that devided into 5 groups: negative control group (PO), positive control group (PA), and 3 treatment groups (P1,P2,P3). The rats in PA, P1,P2 and P3 were injected intraperitonally with aloksan 150 mg/kgBW/day so they have blood glucose level above 200 mg/dL. Treatment group were given eggplant extract by dose P1=383 mg/kgBW/day, P2=686 mg/kgBW/day, and P3=1372 mg/kgBW/day. On day 15 after DM, the rats were terminated and the blood glucose level were measured using a sphectrophotometer. The Result of One Way ANOVA test showed that they was a significant differences between treatment groups and PA, no significant differences between P1 and P3 to PO, but there were a significant differences between P2 and PO. It can be concluded that eggplant extract may lower blood glucose level of DM rats near to normal, but the difference in dose in this study do not affect the magnitude of decrease in blood glucose level.

Authors’ Affiliations

(1)
Faculty of Medicine, Brawijaya University, Malang, Indonesia

Copyright

© Qonita et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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