Figure 2
From: Monogenic hyperinsulinemic hypoglycemia: current insights into the pathogenesis and management
Algorithm for the treatment of hyperinsulinism. Assessing theresponse to diazoxide is a critical step in the management of HI.Patients who fail to respond to diazoxide will most likely haveKATP channel defect and require referral to a specializedcenter with 18 F DOPA PET scan capability. A safetyfast should be 8 to 18 h long depending on the age of the patient. Notethat octreotide is not recommended as pre-operative treatment inneonates with HI due to high rate of treatment failure and risk ofnecrotizing enterocolitis. KATP = ATP-sensitive potassiumchannel, 18 F DOPA PET = 18-fluoroL-3,4-dihydroxyphenylalanine positron emission tomography.