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Table 1 Sexual Function among CAH Women: Relationships with genotype* and surgery

From: Key discussions from the Working Party on Disorders of Sex Development (DSD) evaluation, Foundation Merieux, Annecy, France, March 14-17, 2012

Sexual function

Based on genotype and surgery

Clitoral sensitivity

Highest for nerve sparing and clitoral placement

 

No difference between no surgery and partial resection

 

Poorest with subcutaneous clitoral placement/partial resection

Ability to achieve orgasm

Did not correlate with sensitivity

 

Not different between genotype groups or from controls

Sexual function score

Score correlated with severity of genotype

(9 aspects of sexual life)

Lowest in null phenotype group

 

Lower in null and 12-splice phenotype than controls

Satisfaction with sexual life

No difference between CAH women and controls

 

CAH group with null phenotype (who had more surgical complications) differed from other phenotypes

 

Satisfaction did not correlate with ability to orgasm

  1. *CYP21A2 allele mutations: null, 12-splice, I172N and V281L.