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Table 4 Biochemistry results at baseline and after 3 months and 3 years

From: Weight loss on stimulant medication: how does it affect body composition and bone metabolism? – A prospective longitudinal study

  Baseline 3 months 3 years
(n=25-31) (n=17-25) (n=9-15)
Albumin (g/L) 45.1 ± 3.7 46.5 ± 3.2* 46.1 ± 4.1
Prealbumin (g/L) 0.19 ± 0.04 0.19 ± 0.04 0.20 ± 0.04
Ferritin (ug/L) 28.0 ± 12.6 33.0 ± 13.5 31.4 ± 9.4
Transferrin (g/L) 2.61± 0.30 2.59 ± 0.39 2.63 ± 0.37
Glucose (mmol/L) 4.55 ± 0.35 4.52 ± 0.39 4.57 ± 0.63
Insulin (uU/mL) 4.23 ± 2.92 3.72 ± 2.37 3.07 ± 3.22
Leptin (ng/mL) 4.45 ± 4.03 2.73 ± 2.03* 3.13 ± 1.77
Ghrelin (pmol/L) 385 ± 143 461 ± 135 378 ± 204
IGF-1 (nmol/L) 19.7 ± 7.3 18.0 ± 7.3 31.1 ± 18.0*
IGFBP-3 (ug/mL) 4.07 ± 1.08 4.02 ± 0.87 5.82 ± 2.75*
P1NP (ng/mL) 554 ± 176 458 ± 93* 620 ± 264
C telopeptides (pg/mL) 0.545 ± 0.205 0.504 ± 0.169 0.886 ± 0.518*
Osteocalcin (ng/mL) 50.9 ± 21.9 54.4 ± 13.7 80.9 ± 22.2**
Parathyroid hormone (pmol/L) 1.40 ± 0.96 1.22 ± 0.62 1.99 ± 1.22
Vitamin D (nmol/L) 67.6 ± 23.0 71.6 ± 21.4 69.1 ± 15.8
  1. Mean ± standard deviation shown.
  2. * p<0.05 **p<0.01 compared to baseline, paired t-test.
  3. P1NP: propeptide of type I collagen; IGF-1: insulin-like growth factor 1; IGFBP-3: insulin-like growth factor binding protein 3; Vitamin D: 25-hydroxy vitamin D;
  4. There were significant reductions in P1NP, leptin and albumin in the first 3 months. Over 3 years there were significant increases in IGF-1, IGFBP-3, and C telopeptides and osteocalcin.
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