| |
Baseline
|
3 months
|
3 years
|
|---|
|
(n=25-31)
|
(n=17-25)
|
(n=9-15)
|
|---|
|
Albumin (g/L)
|
45.1 ± 3.7
|
46.5 ± 3.2*
|
46.1 ± 4.1
|
|
Prealbumin (g/L)
|
0.19 ± 0.04
|
0.19 ± 0.04
|
0.20 ± 0.04
|
|
Ferritin (ug/L)
|
28.0 ± 12.6
|
33.0 ± 13.5
|
31.4 ± 9.4
|
|
Transferrin (g/L)
|
2.61± 0.30
|
2.59 ± 0.39
|
2.63 ± 0.37
|
|
Glucose (mmol/L)
|
4.55 ± 0.35
|
4.52 ± 0.39
|
4.57 ± 0.63
|
|
Insulin (uU/mL)
|
4.23 ± 2.92
|
3.72 ± 2.37
|
3.07 ± 3.22
|
|
Leptin (ng/mL)
|
4.45 ± 4.03
|
2.73 ± 2.03*
|
3.13 ± 1.77
|
|
Ghrelin (pmol/L)
|
385 ± 143
|
461 ± 135
|
378 ± 204
|
|
IGF-1 (nmol/L)
|
19.7 ± 7.3
|
18.0 ± 7.3
|
31.1 ± 18.0*
|
|
IGFBP-3 (ug/mL)
|
4.07 ± 1.08
|
4.02 ± 0.87
|
5.82 ± 2.75*
|
|
P1NP (ng/mL)
|
554 ± 176
|
458 ± 93*
|
620 ± 264
|
|
C telopeptides (pg/mL)
|
0.545 ± 0.205
|
0.504 ± 0.169
|
0.886 ± 0.518*
|
|
Osteocalcin (ng/mL)
|
50.9 ± 21.9
|
54.4 ± 13.7
|
80.9 ± 22.2**
|
|
Parathyroid hormone (pmol/L)
|
1.40 ± 0.96
|
1.22 ± 0.62
|
1.99 ± 1.22
|
|
Vitamin D (nmol/L)
|
67.6 ± 23.0
|
71.6 ± 21.4
|
69.1 ± 15.8
|
- Mean ± standard deviation shown.
- * p<0.05 **p<0.01 compared to baseline, paired t-test.
- P1NP: propeptide of type I collagen; IGF-1: insulin-like growth factor 1; IGFBP-3: insulin-like growth factor binding protein 3; Vitamin D: 25-hydroxy vitamin D;
- There were significant reductions in P1NP, leptin and albumin in the first 3 months. Over 3 years there were significant increases in IGF-1, IGFBP-3, and C telopeptides and osteocalcin.
