Table 2 Diagnostic values of basal LH, Estradiol, Testosterone, stimulated LH and the ratio of LH/FSH for Puberty
From: A single sample GnRHa stimulation test in the diagnosis of precocious puberty
Predictors of puberty | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
Basal LH > 0.1 mIU/ml (M) | 100% | 100% | 100% | 100% |
Basal LH > 0.1 mIU/ml (F) | 67% | 100% | 100% | 63% |
Basal Estradiol ≥ 1.5 ng/dL | 50% | 94% | 94% | 52% |
Basal Testosterone ≥ 10 ng/dL | 100% | 100% | 100% | 100% |
LH at 1 h ≥ 5 mIU/ml | 73% | 100% | 100% | 80% |
LH at 3 h ≥ 5 mIU/ml | 83% | 97% | 98% | 74% |
LH at 3 h ≥ 3 mIU/ml | 92% | 75% | 88% | 82% |
LH at 3 h ≥ 7 mIU/ml | 80% | 100% | 100% | 71% |
Basal LH/FSH >1 (M) | 100% | 100% | 100% | 100% |
Basal LH/FSH >1 (F) | 10% | 100% | 100% | 39% |
LH/FSH at 1 h >1(M) | 100% | 100% | 100% | 100% |
LH/FSH at 1 h >1(F) | 50% | 100% | 100% | 53% |
LH/FSH at 3 h >1(M) | 100% | 100% | 100% | 100% |
LH/FSH at 3 h >1(F) | 45% | 100% | 100% | 51% |
LH at 1 h ≥ 5 mIU/ml and basal LH/FSH >1 | 61% | 100% | 100% | 56% |
LH at 3 h ≥ 5 mIU/ml and basal LH/FSH >1 | 16% | 100% | 100% | 38% |
LH at 3 h ≥ 5 mIU/ml and LH/FSH at 1 h >1 | 59% | 100% | 100% | 56% |