Table 1 Diagnostic test results for twin A.
From: Prenatal Virilization Associated with Paternal Testosterone Gel Therapy
Chronologic ageTwin A (months) | Ref.Range # | 0.1 | 12 | 18 | 22 | 23 | 25 | 29 | 34 | 38 |
|---|---|---|---|---|---|---|---|---|---|---|
Total testosterone ng/dL(nM) |
| 9.8 (0.4) | 103(4) | 46 (1.8) | 129 (5.2) | 115 (4.8) | 217 (8.7) | 4.6 (0.18) | 13(0.5) | 2.3 (0.09) |
Androstenedione ng/dL (nM) |
| 71 (2.0) | 64 (1.9) | 46 (1.4) | Â | Â | 55 (1.6) |
| Â | Â |
17-Hydroxyprogesterone ng/dL (nM) | 3–90 (0.1–3) | 82 (2.4) | 17 (0.5) |  | 15 (0.45) | 14 (0.42) |  |
| Â | Â |
17-Hyroxypregnenoloneng/dL (nM) | 14–207 (0.4–7) |  | 135 (4) |  |  |  |  |  |  |  |
Dehydroepiandrosterone ng/dL(nM) | 20–130 (0.6–4) |  | 20(0.6) |  | 47(1.4) | 83 (2.5) |  |  |  |  |
5-Dehydroepiandrosterone-sulfate mcg/dL |
| Â | Â | 11 | Â | Â |
| 22 | Â | Â |
(nM) | ( | Â | Â | (0.44) | Â | Â | ( | (0.88) | Â | Â |
Cortisol ng/dL (nM) | 3–21 (0.9–7) |  | 3(0.9) |  |  |  |  |  |  |  |
Renin ng/mL/hr( | 1–6.5 |  | 6.0 |  |  |  |  |  |  |  |
Estradiol ng/dL (nM) |
| Â | Â | Â |
| Â | Â | Â | Â | Â |
Deoxycorticosterone ng/dL (nM) | 2–34 (0.6–1.0) |  |  |  |
| Â | Â | Â | Â | Â |
DHT ng/dL(nM) |
| Â | Â | Â | Â | Â | 35(1.4) | Â | Â | Â |
Bone Age (mo) | Â | Â | 15 | 18 | 24 | Â | Â | Â | Â | 36 |
3–10(0.07–0.4)
10–17 (0.3–0.6)
10 (
0.03)
10 (
0.3)
5–57
10
0.1–1.4)
0.4)
10)
15 (
0.4)
0.10 (
0.003)
2.0 (
0.06)
3(
0.3)
Prepubertal reference ranges from Esoterix Laboratory Services, Casablanca Hills, CA.
After 0.25 mg of dexamethasone per day for 2 weeks.
AndroGel exposure revealed at 25 months of age.
Prepubertal reference ranges from Esoterix Laboratory Services, Casablanca Hills, CA.
After 0.25 mg of dexamethasone per day for 2 weeks.
AndroGel exposure revealed at 25 months of age.