Table 3 HSDS change from baseline stratified by age at treatment start and gender.

11 years

11 years

-value

10 years

10 years

-value

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

Year 1

759

0.75 ± 0.52

1,169

0.41 ± 0.36

.0001

272

0.78 ± 0.54

324

0.48 ± 0.40

.0001

Year 2

555

1.20 ± 0.68

780

0.85 ± 0.54

.0001

206

1.25 ± 0.65

214

0.91 ± 0.58

.0001

Year 1

96

0.85 ± 1.07

45

0.27 ± 0.40

.0001

46

0.86 ± 0.82

35

0.29 ± 0.45

.0002

Year 2

81

1.26 ± 1.07

24

0.54 ± 0.82

.0033

27

1.33 ± 1.22

23

0.60 ± 0.70

.0114

Year 1

—

—

—

—

—

145

0.56 ± 0.40

101

0.25 ± 0.36

.0001

Year 2

—

—

—

—

—

107

0.84 ± 0.54

66

0.63 ± 0.56

.0168

Year 1

101

0.82 ± 0.53

30

0.27 ± 0.28

.0001

52

0.58 ± 0.55

25

0.41 ± 0.35

.0931

Year 2

63

1.23 ± 0.60

14

0.59 ± 0.51

.0005

29

1.00 ± 0.74

13

0.87 ± 0.51

.5670

Year 1

18

0.53 ± 0.41

12

0.16 ± 0.38

.0212

6

0.31 ± 0.45

5

0.26 ± 0.47

.8565

Year 2

10

0.83 ± 0.84

5

0.25 ± 0.45

.1763

1

0.23 ± —

1

0.10 ± —

—

Year 1

115

0.60 ± 0.44

208

0.38 ± 0.29

.0001

47

0.71 ± 0.37

92

0.35 ± 0.38

.0001

Year 2

83

0.96 ± 0.63

110

0.79 ± 0.51

.0400

33

1.25 ± 0.61

48

0.73 ± 0.62

.0004