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Table 1 Natural history studies of subclinical hypothyroidism in children.

From: Subclinical Hypothyroidism in Children: Normal Variation or Sign of a Failing Thyroid Gland?

Patient population N with SCH Years of f/u Outcomes Ref
Abnormal newborn screening TSH 28 7.2–9.5 years 9 with normal TSH
19 with TSH 4–10
0 with TSH >10
[4]
Children in a single health care system screened in 2002; no known thyroid disease 3,475 Up to 5 years 73.6% with normal TSH
25% with TSH 5.5–10
2% with TSH >10
[3]
Idiopathic SCH—no antibodies, no goiter 92 2 years 38 with normal TSH
43 with TSH 5–10
11 with TSH >10 (10.5–15)
[5]
Autoimmune thyroiditis: nl T4 and TSH 5–64 mU/L 18 Mean of 5.8 years 7 with normal TSH
10 with normal T4, ↑ TSH
1 with low T4, ↑ TSH
[6]
Autoimmune thyroiditis 55 At least 5 years 16 with normal TSH
16 with TSH 1-2x ULN
23 with TSH > 2x ULN
[7]
Patients with SCH maintained on low doses of l-thyroxine 30 Mean of 3.5 years on l-thyroxine then stopped 14 with TSH <5
12 with TSH 5–9.9
4 with TSH 10–15
[9]
Down syndrome: mean age 16.4 ± 10 years 70 2–7 years 19 with normal TSH
46 with SCH
3 with overt hypothyroidism
2 with hyperthyroidism
[10]