Figure 6

(a) Growth chart of a girl (solid circles) with a history of locally advanced retinoblastoma status post right eye enucleation, chemotherapy, and radiotherapy (39. 6 Gy in 35 fractions) to the orbit, completed at the age of 17 months. Bone ages are represented by open triangles. She was diagnosed with growth hormone (GH) deficiency and then gonadotropin-dependent sexual precocity and treated with GH and depot leuprolide, respectively. The patient had menarche at age 8 and achieved a final height of 60 inches, well below mid-parental height (MPH). (b) The patient's identical twin sister (open circles) was already significantly taller by the age of 5 years. She had menarche at age 12 and achieved a final adult height of 63.75 inches.