Figure 2
From: Gonadotropin-Dependent Precocious Puberty: Neoplastic Causes and Endocrine Considerations
(a) A 3-year-old male with neurofibromatosis type 1 (note classic café-au-lait macules) presented with a history of growth acceleration and testicular enlargement. Bone age was advanced by 6 years. Gonadotropin-releasing hormone stimulation confirmed a diagnosis of gonadotropin-dependent precocious puberty, with a peak luteinizing hormone level of 20.9 mIU/mL. (b). MRI demonstrated a large optic pathway glioma (asterisk). (Figures obtained with permission [54].)