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Table 1 Effects of risperidone, olanzapine, haloperidol, quetiapine, clozapine, ziprasidone, and pimozide on prolactin (PRL) level and PRL related side effects [gynecomastia (GCM), galactorrhea (GLR), and irregular menses (IM) in children and adolescents. Weighted averages (adjusted for numbers of subjects per study) are given for the analysis of Roke et al. [31] with the number of studies analyzed shown in parentheses. Subsequent individual studies are separately indicated, with standard deviations in parentheses. Dashes indicate absent data.

From: Hyperprolactinemia with Antipsychotic Drugs in Children and Adolescents

 

Drug

Number

Age (years)

Dose (mg/day)

Duration (weeks)

PRL baseline ng/mL

PRL endpoint ng/mL

% with PRL nl upper limit

% GCM

% GLR

% IM

Roke et al. [31] (20)

risperidone

1390

9.7

1.6

34.8

8.2

21.6

61.7

3.0

0.5

6.2

Migliardi et al. [29]

risperidone

6 (female)

12.8 (2.3)

1.9 (1.1)

52

8.4 (2.1)

23.4 (7.6)

—

—

*

0

  

22 (male)

10.1 (2.8)

1.7 (1.2)

52

6.5 (1.9)

14.9 (8.6)

—

0

—

—

Swadi et al. [30]

risperidone

11

<19

—

6

—

—

91

—

—

—

Calarge et al. [32]

risperidone

107

7–17

—

mean-36

—

—

50

8

11

33

Roke et al. [31] (7)

olanzapine

170

14.4

2.7

28

11.1

24.2

31

6.2

2.8

2.4

Migliardi et al. [29]

olanzapine

6 (female)

14.3 (2.1)

6.7 (3)

52

8.8 (3.8)

18 (5.2)

—

—

0

0

  

7 (male)

14 (1.9)

7.5 (2.5)

52

7.8 (2.4)

11.3 (4.9)

—

0

—

—

Swadi et al. [30]

olanzapine

11

19

—

6

—

—

9

—

—

—

Roke et al. [31]

           

(5)

quetiapine

72

13.9

378.5

49.6

8.4

9.3

0

0

0

0

(4)

haloperidol

56

12.7

7.2

6.5

7.7

29.1

90

6.7

0

15.4

(3)

pimozide

46

10.3

3.7

21.2

9.3

24.7

80

—

—

—

(2)

clozapine

30

14.5

270

6

9.6

11.6

0

0

0

0

(1)

ziprasidone

6

14.5 (1.8)

98 (40)

8.6 (6.6)

8.6 (6.6)

12 (8)

0

0

0

0

  1. *One individual transiently without dosage change.