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Table 2 Absolute changes of individual vital sign parameters following clonidine administration for each study period and overall.

From: Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing

Period Oxygen saturation (%) Heart rate Respiratory rate
  Mean SD P-value Mean SD P –value Mean SD P -value
1 −2.3 1.6 <.001 −26.4 10.6 .000 −10.7 7.1 .000
2 −2.3 2 .001 −20 11.6 .000 −6.9 4.7 .000
3 −2.3 2.7 .005 −11.6 20.6 .047 −6.5 5.9 .002
4 −1.7 1.9 .010 −17.9 9.5 .000 −4.8 5 .007
Overall −2.2 2.0 <.001 −19.3 14.6 <.001 −7.5 6.1 <.001
Period Systolic blood pressure Diastolic blood pressure    
  Mean SD P -value Mean SD P -value    
1 −19.8 13.1 .000 −7.5 15.7 .068    
2 −19.5 12.5 .000 −14.9 23.7 .029    
3 −14.8 11.7 .001 −14.2 8.5 .000    
4 −25.1 20.8 .002 −16.4 13.9 .002    
Overall −19.7 14.6 <.001 −12.8 16.6 .006    
  1. -value was calculated using a paired -test for study periods 1–4; a repeated measurement model with autoregressive correlation structure was used to compute -value for overall comparison.