Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing

Table 2 Absolute changes of individual vital sign parameters following clonidine administration for each study period and overall.

Period	Oxygen saturation (%)			Heart rate			Respiratory rate
	Mean	SD	P-value	Mean	SD	P –value	Mean	SD	P -value
1	−2.3	1.6	<.001	−26.4	10.6	.000	−10.7	7.1	.000
2	−2.3	2	.001	−20	11.6	.000	−6.9	4.7	.000
3	−2.3	2.7	.005	−11.6	20.6	.047	−6.5	5.9	.002
4	−1.7	1.9	.010	−17.9	9.5	.000	−4.8	5	.007
Overall	−2.2	2.0	<.001	−19.3	14.6	<.001	−7.5	6.1	<.001
Period	Systolic blood pressure			Diastolic blood pressure
	Mean	SD	P -value	Mean	SD	P -value
1	−19.8	13.1	.000	−7.5	15.7	.068
2	−19.5	12.5	.000	−14.9	23.7	.029
3	−14.8	11.7	.001	−14.2	8.5	.000
4	−25.1	20.8	.002	−16.4	13.9	.002
Overall	−19.7	14.6	<.001	−12.8	16.6	.006

-value was calculated using a paired -test for study periods 1–4; a repeated measurement model with autoregressive correlation structure was used to compute -value for overall comparison.

ISSN: 1687-9856