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Table 1 Hormone Levels and Ratios with βHCG Stimulation (SI units)

From: 46,XY disorder of sex development due to 17-beta hydroxysteroid dehydrogenase type 3 deficiency: a plea for timely genetic testing

 

Short βHCG protocola

Prolonged βHCG Protocol b

Reference Ranges

 

Baseline

Stimulated

Baseline

Stimulated

 

Androstenedione (A)

4.5

5.4

1.7

20.5

< 3.0 nmol/L

Testosterone (T)

1.1

2.1

< 0.2

10.9

< 14 nmol/L

Dihydrotestosterone (DHT)

227.7

559

N/A

N/A

414–2933 pmol/L

T:A

0.2

0.4

 

0.5

> 0.8

T:DHT

4.8

3.7

N/A

N/A

> 10

  1. Androstenedione (A) (RIA, DIAsource); Testosterone (T) (electrochemiluminescence, Roche); Dihydrotestosterone (DHT) (LC/MS/MS, Esoterix)
  2. a1500 Units βHCG daily for two consecutive days at age 6 weeks. Stimulated levels were measured 24 h following the second injection
  3. b1500 Units βHCG every other day (2 times per week) for 2 weeks at age 18 weeks. Stimulated levels were measured 24 h following the 3rd injection. The Prolonged βHCG Protocol was discontinued when the genetic result became available. The protocols were adapted from [12]
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International Journal of Pediatric Endocrinology

ISSN: 1687-9856

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