Volume 2015 Supplement 1

Abstracts from the 8th APPES Biennial Scientific Meeting

Open Access

Decreasing birth weight is associated with adverse metabolic profile and lower stature in childhood and adolescence

  • José Derraik1,
  • Deborah Rowe1,
  • Wayne Cutfield1 and
  • Paul Hofman1
International Journal of Pediatric Endocrinology20152015(Suppl 1):P110

DOI: 10.1186/1687-9856-2015-S1-P110

Published: 28 April 2015

Objective

We aimed to evaluate the association of birth weight SDS (BWSDS) with insulin resistance, blood pressure, and auxology in children and adolescents born 23–42 weeks of gestation.

Methods

We studied 143 singleton children and adolescents aged 9.3 ± 3.3 years (range 2.0 – 17.9 years). Clinical assessments included auxology, insulin resistance measured by the HOMA2-IR, and blood pressure from sphygmomanometer measurements. Continuous associations were examined and stratified analyses carried out. For the latter, participants were divided into those of below-average birth weight (BBW, <0 SDS) and above-average birth weight (ABW, ≥0 SDS).

Results

Irrespective of gestational age, lower BWSDS was associated with progressively increased insulin resistance (p<0.0001) and fasting insulin concentrations (p<0.0001). Decreasing BWSDS was associated with higher systolic (p=0.011) and diastolic (p=0.006) blood pressure. Lower BWSDS was also associated with decreasing stature (p<0.010). The BBW group was ~40% more insulin resistant than ABW participants (p=0.004), with the former also displaying fasting insulin concentrations 37% higher (p=0.004). BBW participants were 0.34 SDS shorter than those of higher birth weight (p=0.002). On average, BBW participants failed to meet their genetic potential, tending to be shorter than their parents (p=0.065). As a result, when corrected for parents' heights, BBW participants were 0.6 SDS shorter than those born of higher birth weight (p=0.001). Sub-group analyses on participants born appropriate-for-gestational-age (n=128) showed that associations of BWSDS with both insulin resistance and stature remained (although attenuated).

Conclusion

Decreasing BWSDS (even within the normal range) is associated with adverse metabolic profile and lower stature in children and adolescents.

Authors’ Affiliations

(1)
Liggins Institute, University of Auckland

Copyright

© Derraik et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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