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Figure 1 | International Journal of Pediatric Endocrinology

Figure 1

From: Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy

Figure 1

Functional characterisation of K ATP channels with a heterozygous ABCC8 R526C/H627Mfs*20 compound mutation. A, Representative whole-cell time-current density traces at +40 mV recorded from HEK293 cells expressing Kir6.2/SUR1, Kir6.2/SUR1c1879delC, Kir6.2/SUR1R526C and Kir6.2/SUR1R526C + SUR1C1879delC showing the effects of diazoxide (DZX) and tolbutamide (in the presence of diazoxide) (TOL). Current were recorded using a 1 s ramp protocol (-150 mV to 50 mV). B, Summary of the mean current-densities at +40 mV. Values are mean ± S.E.M from 5–7 cells, *P < 0.05, **P < 0.01 compared to control

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International Journal of Pediatric Endocrinology

ISSN: 1687-9856

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