Volume 2013 Supplement 1

7th Asia Pacific Paediatric Endocrine Society (APPES) Biennial Scientific Meeting

Open Access

Correlation between acanthosis nigricans and insulin resistance in obese children in Manado

  • Arief Gunadi1,
  • Vivekenanda Pateda1,
  • Adrian Umboh1 and
  • Kristellina Sangirta Tirtamulia1
International Journal of Pediatric Endocrinology20132013(Suppl 1):P95

DOI: 10.1186/1687-9856-2013-S1-P95

Published: 3 October 2013

Background

Acanthosis Nigricans, which is a skin condition characterized by darkening and thickening of skin caused by papillomatosis and hyperkeratosis has been reported to be linked to insulin resistance and is thought to be a major factors in type 2 diabetes mellitus.

Objective

To determine whether the presence of acanthosis nigricans in obese children is related with insulin resistance.

Methods

We performed a cross sectional analytic observational study. One hundred twenty three obese children, ages 10 – 14 years with and without acanthosis nigricans got examined for insulin resistance using Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR). Diagnosis of acanthosis nigricans is confirmed by a dermatologist. This study took place in Wenang district, Manado, North Sulawesi from October 2009 until January 2010.

Results

Acanthosis nigricans was found positive in 33 children (61.1%). We found insulin resistance in 84.4% of obese children with acanthosis nigricans. There was a positive correlation between acanthosis nigricans and obese children with insulin resistance (r=0.568, p<0.001).

Conclusion

Children with acanthosis nigricans are more likely have insulin resistance. Therefore, we need to identify acanthosis nigricans in obese children for the possibility of diabetes mellitus type 2 so early intervention can be done.

Authors’ Affiliations

(1)
Department of Child Health, Faculty of Medicine, Sam Ratulangi University, DR R.D. Kandou General Hospital

Copyright

© Gunadi et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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