United States multicenter study of factors predicting the persistence of GH deficiency during the transition period between childhood and adulthood

Table 3 Predictors of persistent GH deficiency in patients with history of idiopathic GH deficiency (n = 55)

	≥1 cextra PHD	≥2 extra PHD	IGF-I < -5.3 SDS	IGF-I < -4.0 SDS	IGF-I < -3.0 SDS	IGF-I < -2.0 SDS	IGF-I > -1.6 SDS	IGFBP-3 < -2.0 SDS	Age <4 yr at original Dx	≥1 PHD + IGF-I < -2.0 SDS	IGF-I < -2.0 SDS + age <4 yr at original Dx
Positive Predictive Value (%)	93	100	100	81	73	53	49	100	89	100	100
Negative Predictive Value (%)	83	78	79	82	88	94	100	73	76	83	75
Specificity (%)	97	100	100	91	82	50	38	100	97	100	100
Sensitivity (%)	65	50	55	65	80	95	100	35	42	65	40

Abbreviations: Dx = diagnosis, GH = growth hormone, IGF-I = insulin-like growth factor I, n = number, PHD = pituitary hormone deficiency, SDS = standard deviation score, yr = year.

ISSN: 1687-9856