Parent-reported outcomes in young children with disorders/differences of sex development

Table 4 Parent Proxy-Report questionnaire scores for children with DSD and children with other Endocrine conditions

Proxy-Report Domains	DSD Sample			Endocrine Sample			DSD vs Endocrine
Proxy-Report Domains	n^a	Subscale score^b, median (range)	SDS^c, median (range)	n^a	Subscale score^b, median (range)	SDS, median (range)	p value^d
Anxiety	23	43.60 (36.30, 68.60)	0.64 (−1.86, 1.37)	21	46.00 (36.30, 75.30)	0.40 (−2.53, 1.37)	NS
Depression	23	37.20 (37.20, 65.20)	1.28* (−1.52, 1.28)	22	43.60 (37.20, 60.10)	0.64* (−1.01, 1.28)	NS
Anger	23	43.40 (29.00, 62.70)	0.66 (−1.27, 2.10)	22	42.50 (29.00, 67.70)	0.75 (−1.77, 2.10)	NS
Peer Relations	23	50.60 (27.30, 60.80)	0.06 (−2.27, 1.08)	22	48.25 (19.10, 60.80)	−0.18 (−3.09, 1.08)	NS
Stigma
Mothers	17	1.33 (1.00, 4.00)	−1.04 (−1.41, 1.89)	16	1.70 (1.00, 4.25)	−0.63 (−1.41, 2.17)	NS
Fathers	6	1.13 (1.00, 3.00)	−1.14 (− 1.30, 1.17)	6	1.75 (1.00, 2.50)	−0.37 (− 1.30, 0.56)	NS
Clinic Visit/ Medication							NS
Mothers	16	81.67 (3.33, 100.00)	0.68 (−2.52, 1.43)	17	93.30 (54.17, 100.00)	1.16 (−2.65, 1.43)	NS
Fathers	6	75.00 (40.00, 83.33)	−0.14 (−1.69, 0.23)	6	87.50 (66.67, 100.00)	0.42 (−0.51, 0.97)	NS

^an’s vary by domain due to item responses and not all children take medication. ^bFor anxiety, depression, anger and peer relations, the subscale score represents the PROMIS T-score. ^cSDS standard deviation score, calculated using mean and SD from reference data. ^dp values have been adjusted for multiple comparisons using false discovery rates; significance has been assigned at adjusted p < 0.05. *p < 0.05, compared to SDS of zero. All p values have been adjusted for multiple comparisons

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