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Table 4 Parent Proxy-Report questionnaire scores for children with DSD and children with other Endocrine conditions

From: Parent-reported outcomes in young children with disorders/differences of sex development

Proxy-Report DomainsDSD SampleEndocrine SampleDSD vs Endocrine
naSubscale scoreb, median (range)SDSc, median (range)naSubscale scoreb, median (range)SDS, median (range)p valued
Anxiety2343.60 (36.30, 68.60)0.64 (−1.86, 1.37)2146.00 (36.30, 75.30)0.40 (−2.53, 1.37)NS
Depression2337.20 (37.20, 65.20)1.28* (−1.52, 1.28)2243.60 (37.20, 60.10)0.64* (−1.01, 1.28)NS
Anger2343.40 (29.00, 62.70)0.66 (−1.27, 2.10)2242.50 (29.00, 67.70)0.75 (−1.77, 2.10)NS
Peer Relations2350.60 (27.30, 60.80)0.06 (−2.27, 1.08)2248.25 (19.10, 60.80)−0.18 (−3.09, 1.08)NS
Stigma
 Mothers171.33 (1.00, 4.00)−1.04 (−1.41, 1.89)161.70 (1.00, 4.25)−0.63 (−1.41, 2.17)NS
 Fathers61.13 (1.00, 3.00)−1.14 (− 1.30, 1.17)61.75 (1.00, 2.50)−0.37 (− 1.30, 0.56)NS
Clinic Visit/ Medication      NS
 Mothers1681.67 (3.33, 100.00)0.68 (−2.52, 1.43)1793.30 (54.17, 100.00)1.16 (−2.65, 1.43)NS
 Fathers675.00 (40.00, 83.33)−0.14 (−1.69, 0.23)687.50 (66.67, 100.00)0.42 (−0.51, 0.97)NS
  1. an’s vary by domain due to item responses and not all children take medication. bFor anxiety, depression, anger and peer relations, the subscale score represents the PROMIS T-score. cSDS standard deviation score, calculated using mean and SD from reference data. dp values have been adjusted for multiple comparisons using false discovery rates; significance has been assigned at adjusted p < 0.05. *p < 0.05, compared to SDS of zero. All p values have been adjusted for multiple comparisons