Skip to main content

Table 1 Demographic characteristics of patients for HSDS analysisa

From: Outcomes in children treated with growth hormone for Prader-Willi syndrome: data from the ANSWER Program® and NordiNet® International Outcome Study

Variable

ANSWER Program®

NordiNet® IOS

All

Age at GH start, years

n = 71

n = 58

n = 129

Mean (SD)

4.98 (4.73)

3.74 (4.18)

4.42 (4.51)

Median (range)

3.06 (0.15–17.56)

1.80 (0.39–15.81)

2.15 (0.15–17.56)

Female, %

59%

40%

50%

Baseline BA/CA ratiob

n = 15

1.04 (0.17)

n = 13

0.79 (0.31)

n = 28

0.92 (0.27)

Final BA/CA ratiob

n = 32

1.04 (0.18)

n = 27

0.88 (0.17)

n = 59

0.97 (0.19)

GH baseline dose, mg/kg/d

n = 71

0.03 (0.01)

n = 58

0.03 (0.01)

n = 129

0.03 (0.01)

GH final dose, mg/kg/db

n = 61

0.03 (0.01)

n = 55

0.03 (0.01)

n = 116

0.03 (0.01)

IGF-1 SDSb

n = 31

−0.58 (1.79)

n = 34

− 0.84 (1.72)

n = 65

− 0.71 (1.75)

Baseline height, cm

n = 71

95.00 (33.47)

n = 58

88.75 (27.61)

n = 129

92.19 (31.01)

Baseline weight, kg

n = 71

24.65 (24.22)

n = 58

17.47 (18.56)

n = 129

21.42 (22.07)

Last recorded height, cm

n = 71

124.2 (31.14)

n = 58

122.1 (27.65)

n = 129

123.2 (29.52)

Mid-parental target height, cmb

n = 60

164.1 (25.33)

n = 38

174.5 (8.37)

n = 98

168.1 (21.04)

Baseline HSDS

n = 71

−1.17 (1.40)

n = 58

−1.94 (1.52)

n = 129

− 1.52 (1.50)

Final HSDS

n = 71

−0.28 (1.27)

n = 58

− 0.72 (1.11)

n = 129

− 0.48 (1.22)

Years of follow-up

n = 71

n = 58

n = 129

Mean (SD)

2.39 (1.33)

2.59 (1.29)

2.48 (1.31)

Median (range)

2.57 (0.06, 3.93)

3.10 (0.16, 3.98)

2.63 (0.06, 3.98)

  1. BA bone age, CA chronologic age, GH growth hormone, HSDS height standard deviation score, IGF-1 insulin-like growth factor 1, SDS standard deviation score
  2. aAll values mean (SD) unless otherwise specified
  3. bPatient numbers reduced due to missing data