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Table 2 Adrenal and testicular function after cortrosyn and hCG stimulation obtained at 8 months

From: Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy

CORTROSYN STIMULATION TEST (250 mcg)

Reference value

Baseline

Stimulated (1 h)

ACTH (pg/ml)

6–48

11

 

Cortisol (mcg/dl)

2.8–23

19

29

Aldosterone (ng/dl)

5–90

38

 

Renin (ng/ml/hr)

2–37

7.8

 

17-Hydroxypregnenolone (ng/dl)

42–540

528

1150

17-Hydroxyprogesterone (ng/dl)

< 91

57

182

Androstenedione (ng/dl)

< 10–37

< 10

< 10

DHEA (ng/dl)

< 136

78

114

Testosterone (ng/dl)

< 2.5–10

3.6

3.8

Dihydrotestosterone (ng/dl)

< 3

1.4

 

Corticosterone (ng/dl)

80–1500

871

 

Deoxycorticosterone (ng/dl)

7–49

15

43

11-Deoxycortisol (ng/dl)

< 10–156

54

107

Estrone (pg/ml)

< 15

< 2.5

6

Progesterone (ng/dl)

< 10–15

< 10

52

hCG STIMULATION TEST (15,000 IU over 3 days)

 

Baseline

Day 4

LH (mIU/ml)

0.02–7

0.228

 

FSH (mIU/ml)

0.16–4.1

1.3

 

Testosterone (ng/dl)

< 2.5–10

3.6

587

Dihydrotestosterone (ng/dl)

< 3

1.4

111

Androstenedione (ng/dl)

< 10–37

< 10

15

Estrone (pg/ml)

< 15

< 2.5

3.8

Estradiol (pg/ml)

< 15

< 1

1.5